CC BY-NC-ND 4.0 · Endoscopy 2019; 51(11): 1059-1065
DOI: 10.1055/a-0956-6922
Original article
Owner and Copyright © Georg Thieme Verlag KG 2019

19 G aspiration needle versus 19 G core biopsy needle for endoscopic ultrasound-guided liver biopsy: a prospective randomized trial

Rafael A. Ching-Companioni
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States
,
David L. Diehl
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States
,
Amitpal S. Johal
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States
,
Bradley D. Confer
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States
,
Harshit S. Khara
Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States
› Author Affiliations
Further Information

Publication History

submitted 17 November 2018

accepted after revision 06 June 2019

Publication Date:
23 July 2019 (online)

  

Abstract

Background Endoscopic ultrasound-guided liver biopsy (EUS-LB) is a safe and effective method for accomplishing parenchymal liver biopsy. The aim of this study was to compare a 19 G aspiration needle (FNA) with a 19 G Franseen-tip core biopsy needle (FNB) for EUS-LB.

Methods This was a prospective, parallel group, randomized trial comparing the tissue yields and adequacy of a 19 G FNA needle vs. a 19 G FNB needle for EUS-LB. The primary outcome was length of the longest piece of liver core specimen. Secondary outcomes were aggregate specimen length, number of complete portal triads (CPTs), and adverse events. One transgastric pass and one transduodenal pass were performed with the same needle in each patient. Specimen lengths were measured before and after histological processing.

Results 40 patients referred for EUS-LB were randomized to either the FNA group (n = 20) or the FNB group (n = 20). Both groups had similar patient characteristics. FNB biopsies yielded longer mean (standard deviation) specimen lengths (pre-processing mean 2.09 cm [0.41] vs. mean 1.47 cm [0.46], and post-processing mean 1.78 cm [0.66] vs. mean 1.05 cm [0.42]; both P < 0.001), a longer aggregate specimen length (pre-processing mean 15.78 cm [5.19] vs. 10.89 cm [4.38]; P = 0.003), and more CPTs (mean 42.6 [25] vs 18.1 [9.3]; P < 0.001) compared with the FNA needle. There were no severe adverse events or difference in adverse event rate between the two needles. Post-biopsy pain was noted in 37.5 %.

Conclusion EUS-LB using the FNB needle delivered longer liver biopsy specimens with more CPTs than the regular (non-core) needle.

Table 1s , 2s, Fig. 1s – 3s