Abstract
Background Endoscopic ultrasound-guided liver biopsy (EUS-LB) is a safe and effective method
for accomplishing parenchymal liver biopsy. The aim of this study was to compare a
19 G aspiration needle (FNA) with a 19 G Franseen-tip core biopsy needle (FNB) for
EUS-LB.
Methods This was a prospective, parallel group, randomized trial comparing the tissue yields
and adequacy of a 19 G FNA needle vs. a 19 G FNB needle for EUS-LB. The primary outcome
was length of the longest piece of liver core specimen. Secondary outcomes were aggregate
specimen length, number of complete portal triads (CPTs), and adverse events. One
transgastric pass and one transduodenal pass were performed with the same needle in
each patient. Specimen lengths were measured before and after histological processing.
Results 40 patients referred for EUS-LB were randomized to either the FNA group (n = 20)
or the FNB group (n = 20). Both groups had similar patient characteristics. FNB biopsies
yielded longer mean (standard deviation) specimen lengths (pre-processing mean 2.09 cm
[0.41] vs. mean 1.47 cm [0.46], and post-processing mean 1.78 cm [0.66] vs. mean 1.05 cm
[0.42]; both P < 0.001), a longer aggregate specimen length (pre-processing mean 15.78 cm [5.19]
vs. 10.89 cm [4.38]; P = 0.003), and more CPTs (mean 42.6 [25] vs 18.1 [9.3]; P < 0.001) compared with the FNA needle. There were no severe adverse events or difference
in adverse event rate between the two needles. Post-biopsy pain was noted in 37.5 %.
Conclusion EUS-LB using the FNB needle delivered longer liver biopsy specimens with more CPTs
than the regular (non-core) needle.
