Abstract
We studied the effects of supramaximal interval exercise (SIE) with or without antihypertensive
medication (AHM) on 21-hr blood pressure (BP) response. Twelve hypertensive patients
chronically medicated with AHM, underwent three trials in a randomized order: a) control
trial without exercise and substituting their AHM with a placebo (PLAC); b) placebo
medicine and a morning bout of SIE (PLAC+SIE), and c) combining AHM and exercise (AHM+SIE).
Acute and ambulatory blood pressure responses were measured for 21-hr after treatment.
20 min after treatment, systolic blood pressure (SBP) readings were reduced, similar
to readings after PLAC+SIE (−9.7±6.0 mmHg, P<0.001) and AHM+SIE (−10.4±7.9 mmHg, P=0.001).
21 h after treatment, SBP remained reduced after PLAC+SIE (125±12 mmHg, P=0.022) and
AHM+SIE (122±12 mmHg, P=0.013) compared to PLAC (132±16 mmHg). The BP reduction in
PLAC+SIE faded out at 4 a.m., while in AHM+SIE it continued overnight. At night, BP
reduction was larger in AHM+SIE than PLAC+SIE (–5.6±4.0 mmHg, P=0.006). Our data shows
that a bout of supramaximal aerobic interval exercise in combination with ARB medication
in the morning elicits a sustained blood pressure reduction lasting at least 21-h.
Thus, the combination of exercise and angiotensin receptor blocker medication seems
superior to exercise alone for acutely decreasing blood pressure.
Key words
antihypertensive drugs - metabolic syndrome X - aerobic exercise - high blood pressure
- hypertension.
