Horm Metab Res 2019; 51(06): 389-395
DOI: 10.1055/a-0887-2770
Endocrine Research
© Georg Thieme Verlag KG Stuttgart · New York

Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity

Gregorio Caimi
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
,
Baldassare Canino
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
,
Maria Montana
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
,
Caterina Urso
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
,
Vincenzo Calandrino
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
,
Rosalia Lo Presti
2  Dipartimento di Scienze Psicologiche, Pedagogiche, dell’Esercizio Fisico e della Formazione, Università di Palermo, Palermo, Italy
,
Eugenia Hopps
1  Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy
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Publikationsverlauf



received 20. April 2018

Publikationsdatum:
10. Mai 2019 (eFirst)

Abstract

The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, the increase in oxidative stress and the dysregulation of the matrix metalloprotease (MMP) concentration and activity. In a group of adults with obesity, divided in 2 subgroups according to the body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, expressed as protein carbonyl groups (PCs), plasma gelatinases (MMP-2 and MMP-9), and their tissue inhibitors (TIMP-1 and TIMP-2). In the whole group, as well as in the 2 subgroups (with BMI 30–35 or BMI>35) of obese subjects, we observed an increase in TBARS, PCs, MMP-2, and MMP-9, and also TIMP-1 and TIMP-2 in comparison with the control group. A positive correlation between TBARS and PCs emerged in obese subjects and persisted after dividing obese subjects according to BMI. The correlation between MMP-2 and TIMP-2 was not statistically significant, while a significant correlation was present between MMP-9 and TIMP-1. The correlations between the markers of oxidative stress (TBARS and PCs) and those of the MMP/TIMP profile indicated a more marked influence of protein oxidation on MMPs and TIMPs in comparison with TBARS. The innovative aspect of our study was the simultaneous evaluation of oxidative stress markers and MMP/TIMP profile in adult obese subjects. We observed significant alterations and correlations that may negatively influence the clinical course of the disease.