Planta Med 2019; 85(11/12): 815-824
DOI: 10.1055/a-0873-8622
Biological and Pharmacological Activity
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Georg Thieme Verlag KG Stuttgart · New York

The Nonvolatile and Volatile Metabolites of Prangos ferulacea and Their Biological Properties[*]

Maurizio Bruno
1   Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Parco dʼOrleans II, Palermo, Italy
,
Vincenzo Ilardi
2   Department of Earth and Marine Sciences (DISTeM), University of Palermo, Palermo, Italy
,
Giulio Lupidi
2   Department of Earth and Marine Sciences (DISTeM), University of Palermo, Palermo, Italy
,
Luana Quassinti
3   School of Pharmacy, University of Camerino, Camerino, Italy
,
Massimo Bramucci
3   School of Pharmacy, University of Camerino, Camerino, Italy
,
Dennis Fiorini
4   School of Science and Technologies, University of Camerino, Camerino, Italy
,
Alessandro Venditti
5   Department of Chemistry, University of Rome “La Sapienza”, Rome, Italy
,
Filippo Maggi
3   School of Pharmacy, University of Camerino, Camerino, Italy
› Institutsangaben
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Publikationsverlauf

received 18. Dezember 2018
revised 01. März 2019

accepted 05. März 2019

Publikationsdatum:
20. März 2019 (online)

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Abstract

Prangos ferulacea (L.) Lindl. (Fam. Apiaceae), an orophilous species of eastern Mediterranean and western Asia, possesses a number of biological properties that are worthy of exploitation in different fields. Phytochemical investigations revealed the presence of coumarins, prenyl-coumarins, and furano-coumarins as the main constituents of this species, as well as several flavonoids. Among prenyl-coumarins, osthol is a promising apoptotic agent quite selective toward cancer cells. In addition, the essential oils have been extensively investigated, and several chemotypes have been identified. This work reviews the literature on this species published between 1965 and 2018, describes its volatile and nonvolatile metabolites, and outlines its pharmacological effects.

* Dedicated to Professor Dr. Cosimo Pizza in recognition of his important contributions to natural product research on the occasion of his 70th birthday in 2019.