Aktuelle Dermatologie 2019; 45(08/09): 377-385
DOI: 10.1055/a-0868-1056
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Lichenoide Dermatosen der Vulva

Lichenoid Dermatoses of the Vulva
F. Gieseking
1   Frauenarztpraxis, Hamburg
,
I. Moll
2   DermatoMed, Privatärztliche Praxis für Dermatologie im Facharztzentrum an der Kampnagelfabrik, Hamburg
› Author Affiliations
Further Information

Publication History

Publication Date:
16 May 2019 (online)

Zusammenfassung

Dieser Artikel gibt einen aktuellen Überblick über die 3 lichenoiden Erkrankungen der Vulva. Es handelt sich um chronische Dermatosen. Sie verursachen nicht notwendigerweise Beschwerden und fallen bisweilen erst bei sorgfältiger Anamnese und der gynäkologischen Untersuchung auf. Während der vulväre Lichen simplex chronicus als harmlos angesehen werden kann, führen Lichen planus und Lichen sclerosus zu langanhaltenden und hartnäckigen Beschwerden. Der Lichen sclerosus und der Lichen planus werden als Risikofaktoren für die Entwicklung eines HPV-negativen Vulvakarzinoms angesehen. Die meisten Frauen mit malignen Befunden an der Vulva hatten zuvor häufig einen Lichen sclerosus oder einen Lichen planus. Die Ursachen der lichenoiden Erkrankungen gelten als unbekannt. Eine Störung des Immunsystems wird angenommen. Ein abschließendes Urteil zu diesen Erkrankungen ist noch nicht möglich.

Abstract

This article provides an overview on the three lichenoid diseases of the vulva, which are chronic dermatoses. They do not necessarily cause discomfort and may be only noticed by medical history and careful gynaecological examination. While vulvar lichen simplex chronicus may be considered harmless, vulvar lichen planus and particularly vulvar lichen sclerosus cause long-term and often persistent complaints. Both are considered as risk factors for the development of HPV-negative vulvar carcinoma. Most women with malignancies at the vulva previously suffered from lichen sclerosus or sometimes lichen planus. The causes of the lichenoid diseases are unknown. A malfunction of the immune system is assumed. A final verdict on these diseases is not yet possible.

 
  • Literatur

  • 1 Altmeyer P. Lichen simplex chronicus. Altmeyers Enzyklopädie. www.enzyklopaedie-dermatologie.de/ Gezogen 2018-11
  • 2 Fruchter R, Melnick L, Pomeranz MK. Lichenoid vulvar disease: A review. Int J Womens Dermatol 2017; 3: 58-64
  • 3 van der Meijden WI, Boffa MJ, Ter Harmsel WA. et al. 2016 European guideline for the management of vulval conditions. J Eur Acad Dermatol Venereol 2017; 31: 925-941
  • 4 Stockdale CK, Boardman L. Diagnosis and Treatment of Vulvar Dermatoses. Obstet Gynecol 2018; 131: 371-386
  • 5 Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis]. Entwicklungsstufe: S2k. Letzte Überarbeitung März 2015. Gültigkeit bis 31. Dezember 2018 verlängert. www.awmf.org
  • 6 Bates SM, Dilke-Wing G. Determination of iron status in women attending genitourinary clinics with pruritus vulvae. Sex Transm Infect 2006; 82: 489-490
  • 7 Goldstein AT, Parneix-Spake A, McCormick CL. et al. Pimecrolimus cream 1% for treatment of vulvar lichen simplex chronicus: an open-label, preliminary trial. Gynecol Obstet Invest 2007; 64: 180-186
  • 8 Kelekci HK, Uncu HG, Yilmaz B. et al. Pimecrolimus 1 % cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: a prospective non-controlled case series. J Dermatolog Treat 2008; 19: 274-278
  • 9 Corazza M, Borghi A, Minghetti S. et al. Effectiveness of silk fabric underwear as an adjuvant tool in the management of vulvar lichen simplex chronicus: results of a double-blind randomized controlled trial. Menopause 2015; 22: 850-856
  • 10 Kirtschig G, Becker K, Günthert A. et al. Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus. J Eur Acad Dermatol Venereol 2015; 29: e1-e43 Full text available on: https://www.euroderm.org/home/Guidelines/EDF-Guidelines.html (expiry prolongated until September 2020)
  • 11 Regauer S. Anogenital lichen planus often confused with lichen sclerosis. J Gynecol Women’s Health 2017; 7: 555721
  • 12 Lewin MR, Hick RW, Selim MA. Lichenoid Dermatitis of the Vulva: Diagnosis and Differential Diagnosis for the Gynecologic Pathologist. Adv Anat Pathol 2017; 24: 278-293
  • 13 Kreuter A, Kryvosheyeva Y, Terras S. et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol 2013; 93: 238-241
  • 14 Workowski KA, Bolan GA. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64: 1-137 https://www.cdc.gov/std/tg2015/default.htm
  • 15 Heymann WR, Ellis DL. Borrelia burgdorferi Infections in the United States. J Clin Aesthet Dermatol 2012; 5: 18-28
  • 16 Eisendle K, Grabner T, Kutzner H. et al. Possible role of Borrelia burgdorferi sensu lato infection in lichen sclerosus. Arch Dermatol 2008; 144: 591-598
  • 17 Eberz B, Berghold A, Regauer S. High prevalence of concomitant anogenital lichen sclerosus and extragenital psoriasis in adult women. Obstet Gynecol 2008; 111: 1143-1147
  • 18 McPherson T, Cooper S. Vulval lichen sclerosus and lichen planus. Dermatol Ther 2010; 23: 523-532
  • 19 Day T, Otton G, Jaaback K. et al. Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?. J Low Genit Tract Dis 2018; 22: 159-165
  • 20 Micheletti L, Preti M, Radici G. et al. Vulvar Lichen Sclerosus and Neoplastic Transformation: A Retrospective Study of 976 Cases. J Low Genit Tract Dis 2016; 20: 180-183
  • 21 Hieta N, Kurki S, Rintala N. et al. Associtation of vulvar melanoma with lichen sclerosus. Acta Derm Venerol 2019; 99: 339-240 Epub 6 December 2018
  • 22 Selk A. A Survey of Experts Regarding the Treatment of Adult Vulvar Lichen Sclerosus. J Low Genit Tract Dis 2015; 19: 244-247
  • 23 Chi CC, Kirtschig G, Baldo M. et al. Systematic review and meta-analysis of randomized controlled trials on topical interventions for genital lichen sclerosus. J Am Acad Dermatol 2012; 67: 305-312
  • 24 Corazza M, Borghi A, Minghetti S. et al. Clobetasol propionate vs. mometasone furoate in 1-year proactive maintenance therapy of vulvar lichen sclerosus: results from a comparative trial. J Eur Acad Dermatol Venereol 2016; 30: 956-961
  • 25 Lee A, Bradford J, Fischer G. Long-term management of adult vulvar lichen sclerosus: A prospective cohort study of 507 women. JAMA Dermatol 2015; 151: 1061-1067
  • 26 Funaro D, Lovett A, Leroux N. et al. A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05 % versus topical tacrolimus 0.1 % in patients with vulvar lichen sclerosus. J Am Acad Dermatol 2014; 71: 84-91
  • 27 Shi L, Miao F, Zhang LL. et al. Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus. Acta Derm Venereol 2016; 96: 684-688
  • 28 Tadir Y, Gaspar A, Lev-Sagie A. et al. Light and energy based therapeutics for genitourinary syndrome of menopause: Consensus and controversies. Lasers Surg Med 2017; 49: 137-159
  • 29 LeCleach L, Chosidow O. Clinical practice. Lichen planus. N Engl J Med 2012; 366: 723-32
  • 30 Omal PM, Jacob V, Prathap A. et al. Prevalence of Oral, Skin, and Oral and Skin Lesions of Lichen Planus in Patients Visiting a Dental School in Southern India. Indian J Dermatol 2012; 57: 107-109
  • 31 Cooper SM, Wojnarowska F. Influence of treatment of erosive lichen planus of the vulva on its prognosis. Arch Dermatol 2006; 142: 289-294
  • 32 Belfiore P, Di Fede O, Cabibi D. et al. Prevalence of vulval lichen planus in a cohort of women with oral lichen planus: an interdisciplinary study. Br J Dermatol 2006; 155: 994-998
  • 33 Nagao Y, Sata M, Tanikawa K. et al. Lichen planus and hepatitis C virus in the northern Kyushu region of Japan. Eur J Clin Invest 1995; 25: 910-914
  • 34 Sánchez-Pérez J, De Castro M, Buezo GF. et al. Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection. Br J Dermatol 1996; 134: 715-719
  • 35 Birkenfeld S, Dreiher J, Weitzman D. et al. A study on the association with hepatitis B and hepatitis C in 1557 patients with lichen planus. J Eur Acad Dermatol Venereol 2011; 25: 436-440
  • 36 Shengyuan L, Songpo Y, Wen W. et al. Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol 2009; 145: 1040-1047
  • 37 Pinelli S, Basile S, Benedetti Panici P. et al. Association between HCV infection and cutaneous-mucosal lichen planus: an update. Eur J Dermatol 2017; 27: 329-331
  • 38 Cooper SM, Kirtschig G, Jeffery KJ. et al. No association between hepatitis B or C viruses and vulval lichen planus in a UK population. BJOG 2004; 111: 271-273
  • 39 Fiorino S, Bacchi-Reggiani L, de Biase D. et al. Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review. World J Gastroenterol 2015; 21: 12896-12953
  • 40 Halonen P, Jakobsson M, Heikinheimo O. et al. Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland. Int J Cancer 2018; 142: 18-22
  • 41 Regauer S, Reich O, Eberz B. Vulvar cancers in women with vulvar lichen planus: a clinicopathological study. J Am Acad Dermatol 2014; 71: 698-707
  • 42 Regauer S, Eberz B, Reich O. Human Papillomavirus-Induced Squamous Intraepithelial Lesions in Vulvar Lichen Planus. J Low Genit Tract Dis 2016; 20: 360-364
  • 43 Preti M, Micheletti L, Privitera S. et al. Vulvar Lichen Planus: A Risk Factor for Vulvar High-Grade Squamous Intraepithelial Lesion Recurrence?. J Low Genit Tract Dis 2018; 22: 264-265
  • 44 Simpson RC, Thomas KS, Leighton P. et al. Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. Br J Dermatol 2013; 169: 337-343
  • 45 Helgesen AL, Warloe T, Pripp AH. et al. Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial. Br J Dermatol 2015; 173: 1156-1162
  • 46 Hettiarachchi PVKS, Hettiarachchi RM, Jayasinghe RD. et al. Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double-blinded, randomized clinical trial in Sri Lanka. J Investig Clin Dent 2017; 8
  • 47 Goldstein AT, Thaci D, Luger T. Topical calcineurin inhibitors for the treatment of vulvar dermatosis. Eur J Obstet Gynecol Reprod Biol 2009; 146: 22-29
  • 48 Kurman RJ. ed. WHO Classification of Tumours of Female Reproductive Organs. WHO; 2014
  • 49 Bornstein J, Bogliatto F, Haefner HK. et al. The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of vulvar Squamous Intraepithelial Lesions. J Lower Gen Tract Dis 2016; 20: 11-14
  • 50 Tavassoeli FA. et al. Pathology and Genetics of Tumours of the Breast and Female Genital Organs (Who/IARC Classification of Tumours). WHO; 2003
  • 51 Sideri M. et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 2005; 50: 807-810
  • 52 Joura EA, Leodolter S, Hernandez-Avila M. et al. Efficacy of a quadrivalent prophylactic human papillomovirus (types 6, 11, 16, 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693-1702
  • 53 Joura EA, Garland SM, Paavonen J. et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. BMJ 2012; 344: e1401
  • 54 Reyes MC, Cooper K. An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. J Clin Pathol 2014; 67: 290-294
  • 55 DGGG Leitlinienprogramm. Diagnostik, Therapie und Nachsorge des Vulvakarzinoms und seiner Vorstufen. S2k Leitlinie, Stand August 2015, Version 1.2. www.awmf.org
  • 56 Watkins JC, Yang E, Crum CP. et al. Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. Int J Gynecol Pathol 2018; 38: 175-182
  • 57 Hoang LN, Park KJ, Soslow RA. et al. Squamous precursor lesions of the vulva: current classification and diagnostic challenges. Pathology 2016; 48: 291-302
  • 58 Darragh TM, Colgan TJ, Thomas Cox J. et al. The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Int J Gynecol Pathol 2013; 32: 76-115
  • 59 Joura EA, Giuliano AR, Iversen OE. et al. A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women. N Engl J Med 2015; 372: 711-723
  • 60 Lewis FM, Tatnall FM, Velangi SS. et al. British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. Br J Dermatol 2018; 178: 839-853
  • 61 Moyal-Barracco M, Wendling J. Vulvar dermatosis. Best Practice & Research Clinical Obstetrics and Gynaecology 2014; 28: 946-958
  • 62 AG HPV der Ständigen Impfkommission (STIKO). Wissenschaftliche Begründung für die Empfehlung der HPV-Impfung für Jungen im Alter von 9 bis 14 Jahren. Epid Bull 2018; 26: 233-250