Exp Clin Endocrinol Diabetes 2020; 128(01): 43-51
DOI: 10.1055/a-0859-7168
Article
© Georg Thieme Verlag KG Stuttgart · New York

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis

Fuchsia D. Gold-Smith
1  School of Medicine, University of Auckland, Auckland, New Zealand
,
Ruma G. Singh
1  School of Medicine, University of Auckland, Auckland, New Zealand
,
Maxim S. Petrov
1  School of Medicine, University of Auckland, Auckland, New Zealand
› Author Affiliations
Acknowledgement: This study was part of the Clinical and epidemiological inveStigations in Metabolism, nutrition, and pancreatic diseaseS (COSMOS) programme. COSMOS is supported in part by the Auckland Medical Research Foundation (grant 1116021 to Associate Professor Max Petrov), which played no role in the study design; collection, analysis, or interpretation of data; or writing of the manuscript.
Further Information

Publication History

received 21 November 2018
revised 14 January 2019

accepted 18 February 2019

Publication Date:
14 March 2019 (online)

Abstract

Aim The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies.

Methods This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Fasting venous blood was collected to measure motilin, glycated haemoglobin, and fasting blood glucose. Linear regression analyses were conducted to investigate the associations between glycaemic control and gastrointestinal motility in unadjusted and adjusted models.

Results Motilin was significantly higher in individuals with diabetes across all adjusted models, with the highest ß-coefficient (95% confidence interval) of 588.89 (138.50, 1039.28); P=0.010. Fasting blood glucose was significantly associated with motilin across all models, with the highest ß-coefficient (95% confidence interval) of 156.30 (55.49, 257.10); P=0.002. Glycated haemoglobin was significantly associated with motilin in one adjusted model with ß-coefficient (95% confidence interval) of 18.78 (1.53, 36.02); P=0.033. Gastroparesis cardinal symptom index was not significantly associated with any measure of glycaemic control.

Conclusions Diabetes in individuals after acute pancreatitis appears to be characterised by elevated plasma motilin but not gastroparesis cardinal symptom index. The role of motilin in this setting warrants further investigations.