Z Geburtshilfe Neonatol
DOI: 10.1055/a-0842-6941
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey

Umit Yasemin Sert
1  Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Perinatology, Ankara, Turkey
,
A. Seval Ozgu-Erdinc
1  Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Perinatology, Ankara, Turkey
,
Sibel Saygan
1  Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Perinatology, Ankara, Turkey
,
Yaprak Engin-Ustun
2  Obstetrics and Gynecology, Ankara, Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Turkey
› Author Affiliations
Further Information

Publication History

received 07 November 2018

accepted 14 January 2019

Publication Date:
04 March 2019 (online)

Abstract

Objective The present study aimed to determine herpes simplex virus (HSV) infection during pregnancy, serologic status of symptomatic patients, and the frequency of PCR and culture positivity and neonatal disease in an obstetric population.

Materials and methods Sera of 1,690 women with genital lesions were tested for HSV IgM and/or HSV IgG between 2008 and 2017. All the patients were evaluated by PCR and viral culture to demonstrate genital herpes infection.

Results The frequency of HSV IgG and IgM seropositivity was 73.8% (1245/1685) and 28.6% (484/1690). The number with a positive viral culture was 288, whereas positive PCR was 305. Five infants had localized skin lesions of HSV infection at the time of birth.

Conclusion This study shows the serologic status, viral culture and PCR testing results of pregnant women who had a symptomatic genital HSV infection and efficacy of management strategies to prevent neonatal herpes infection.

Condensed Content