Horm Metab Res 2019; 51(03): 157-164
DOI: 10.1055/a-0841-6638
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Amir Hadi
1   Department of Clinical Nutrition, School of Nutrition & Food Sciences, Food Security Research Center , Isfahan University of Medical Sciences, Isfahan, Iran
2   Halal Research Center of IRI, FDA, Tehran, Iran
Ehsan Ghaedi
3   Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
4   Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
Sajjad Moradi
2   Halal Research Center of IRI, FDA, Tehran, Iran
5   Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Makan Pourmasoumi
6   Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran
Abed Ghavami
7   Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
Marzieh Kafeshani
8   Department of Community Nutrition, School of Nutrition & Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
› Author Affiliations
Further Information

Publication History

received 20 July 2018

accepted 22 January 2019

Publication Date:
12 March 2019 (online)


Melatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta—analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potential RCTs with information on melatonin supplementation and BP. Mean Differences (MD) were pooled using a random-effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Pooling 5 RCTs (6 treatment arms) together identified significant reduction for SBP (MD: −3.43 mmHg, 95% confidence interval (CI): −5.76 to −1.09, p=0.004) and DBP (MD: −3.33 mmHg, 95% CI: −4.57 to −2.08, p<0.001) after supplementation with melatonin compared with control treatment. The sensitivity analysis indicated that the results were robust. We did not observe any evidence regarding publication bias. The findings of this meta-analysis support the overall favorable effect of melatonin supplementation on BP regulation.

Supplementary Material

  • References

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