Ultraschall in Med
DOI: 10.1055/a-0837-0791
Letter to the Editor
© Georg Thieme Verlag KG Stuttgart · New York

SonoVue® Does Not Appear to Cross the Placenta as Observed During an Examination Aimed at Confirming a Diagnosis of Liver Echinococcosis in a Pregnant Woman

Vincent Schwarze
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Constantin Marschner
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Giovanna Negrão de Figueiredo
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Katharina Mueller-Peltzer
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Jens Neumann
2  Institute of Pathology, Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Johannes Rübenthaler
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
,
Dirk-André Clevert
1  Department of Radiology, Interdisciplinary Ultrasound Center, Hospital of the Ludwig-Maximilians-University Munich (LMU), Munich, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
07 February 2019 (eFirst)

We would like to report the observation of the distribution of SonoVue® based on an abdominal examination we carried out in a pregnant woman. A 34-year-old pregnant woman (first trimester, 11 weeks of pregnancy) was assessed in our Interdisciplinary Ultrasound Unit of the Radiology Department due to diagnostic evaluation of epigastric pain with radiation to the lower abdomen. Liver enzymes, AP, CRP, bilirubin, albumin white blood cell count were all within range. Ultrasound in combination with serology suggested the diagnosis of hepatic cystic echinococcosis, but an off-label contrast-enhanced ultrasound exam was carried out after getting the patient’s informed consent in order to rule out a cystic malignancy which would have impacted the management of the pregnancy ([Fig. 1a, b]). We used the abdominal examination as an opportunity to observe the distribution of the ultrasound contrast agent in the uterus. No fetal contrast enhancement could be seen during the CEUS examination, indicating that microbubbles did not cross the placental barrier ([Fig. 2]).