Nuklearmedizin 2019; 58(01): 50-51
DOI: 10.1055/a-0808-0832
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Iodine Avid Papillary Thyroid Cancer Showing PSMA-Expression in 68Ga-PSMA Ligand PET/CT

Christina Nguyen Ngoc
1  Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Klinik für Nuklearmedizin
,
Christian Happel
1  Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Klinik für Nuklearmedizin
,
Amir Sabet
1  Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Klinik für Nuklearmedizin
,
Wolf Otto Bechstein
2  Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Zentrum der Chirurgie
,
Frank Grünwald
1  Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Klinik für Nuklearmedizin
› Author Affiliations
Further Information

Publication History

Publication Date:
15 February 2019 (online)

Introduction

Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein highly expressed by prostate cancer. Ga-68-labeled PSMA analogues have been recently used for PET/CT imaging. PSMA expression has been detected in neovasculature of various solid tumors including thyroid cancers. The enzymatic function of PSMA is currently not completely understood. However, high expression of PSMA in thyroid cancers is correlated with poor differentiation and has been shown in mainly anaplastic and follicular types [1], [3], [5]. To date, only one case reported PSMA expression in a patient with radioiodine refractory papillary thyroid cancer [2]. Here we report the first case of intensive PSMA expression in iodine-avid, newly diagnosed papillary thyroid cancer. This case simultaneously demonstrates an autonomous thyroid nodule with no PSMA expression.