Horm Metab Res 2019; 51(02): 120-126
DOI: 10.1055/a-0801-8917
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery

Ali Afshari
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Margaret Keil
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Charalampos Lyssikatos
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Elena Belyavskaya
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Nuria Valdés
3  Service of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
,
Fatima A. Chowdhry
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Kian Parsa
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Yasaman Ardeshirpour
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Randall Pursley
4  Section on Signal Processing & Instrumentation, Computational Biosciences and Engineering Laboratory, Office of Intramural Research (OIR), Center for Information Technology (CIT), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Siddharth Khare
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Jana M. Kainerstorfer
5  Assistant Professor of Biomedical Engineering, College of Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
,
Prashant Chittiboina
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Maya B. Lodish
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Thomas A. Mazzuchi
6  Professor and Department Chair of Engineering Management $ System Engineering Department, Engineering and Applied Science School, George Washington University, Washington, DC, USA
,
Amir H. Gandjbakhche
1  Section on Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
,
Constantine A. Stratakis
2  Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA
› Author Affiliations
Further Information

Publication History

received  02 April 2018

accepted  08 November 2018

Publication Date:
02 January 2019 (eFirst)

Abstract

We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3–6 months, and 13 patients 12 months post-operatively. On all patients, we used multi-spectral imaging (MSI) to evaluate hemodynamic distributions as well as water content at a specific area of the face. We found a decrease in blood volume fraction after vs. before surgical treatment in the tested facial area in 37 of the 40 patients, as determined with biochemical markers (p<0.001). All patients that were followed up for up to 12 months showed the same decrease from preoperative values and they remained in remission from CD. We conclude that MSI can be used for the evaluation of remission from CD, at least in the immediate post-operative period and up to one year after surgery. The use of this technology can supplement biochemical and other testing for the evaluation of the various treatment modalities available for patients with CD.

Supplementary Material