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Drug Res (Stuttg) 2019; 69(06): 305-313
DOI: 10.1055/a-0797-3657
Review
© Georg Thieme Verlag KG Stuttgart · New York

An Overview on Genistein and its Various Formulations

Neha Jaiswal
1   Department of Pharmaceutics, Integral University, Lucknow, India
,
Juber Akhtar
1   Department of Pharmaceutics, Integral University, Lucknow, India
,
Satya Prakash Singh
1   Department of Pharmaceutics, Integral University, Lucknow, India
,
Badruddeen,
Farogh Ahsan
2   Department of Pharmacology, Integral University, Lucknow, Inidia
› Author Affiliations
Further Information

Publication History

received 11 June 2018

accepted 04 November 2018

Publication Date:
05 December 2018 (online)

Also available at
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Abstract

Genistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer. Numerous factors comprising genetic, epigenetic and transcriptomic alterations are evidenced to be responsible for breast, prostate and lung cancer. In present review, an overview on genistein, the various analytical methods and drug delivery approaches to determine genistein in the formulations are discussed. It may help to develop novel formulations with better solubility and bioavailability of genistein. The tumor cell scan may be targeted to form a stable genistein formulation.

Key words

apoptosis - breast cancer - genistein - nanoformulations
 

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