Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey

Dirk Müller-Wieland; Christiane Altenburg; Heiko Becher; Janine Burchard; Anett Frisch; Jan Gebhard; Jutta Haas; Volker Harth; Jörg Heeren; Johannes Hengelbrock; Maximilian von Karais; Birgit Knebel; Jörg Kotzka; Bernd Löwe; Nikolaus Marx; Hans Pinnschmidt; Alexandra Preisser; Matthias Rose; Barbara Sawitzky-Rose; Ludger Scheja; Claudia Terschüren; Monika Töller; Eik Vettorazzi; Karl Wegscheider

doi:10.1055/a-0767-6361

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2020; 128(12): 777-787
DOI: 10.1055/a-0767-6361

Article

Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey

Dirk Müller-Wieland

¹Department of Medicine I, University Hospital Aachen, Aachen, Germany

,

Christiane Altenburg

²Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Heiko Becher

³Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Janine Burchard

⁴Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany

,

Anett Frisch

⁴Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany

,

Jan Gebhard

⁵Aeromedical Center Lufthansa, Hamburg, Germany

,

Jutta Haas

⁴Asklepios Medical School Campus Hamburg, Semmelweis University, Hamburg, Germany

,

Volker Harth

⁶Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Jörg Heeren

⁷Department of Biochjemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Johannes Hengelbrock

³Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Maximilian von Karais

⁵Aeromedical Center Lufthansa, Hamburg, Germany

,

Birgit Knebel

⁸Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Düsseldorf, Leibniz Center for Diabetes Research, Düsseldorf, Germany

,

Jörg Kotzka

⁸Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Düsseldorf, Leibniz Center for Diabetes Research, Düsseldorf, Germany

,

Bernd Löwe

⁹Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Nikolaus Marx

¹Department of Medicine I, University Hospital Aachen, Aachen, Germany

,

Hans Pinnschmidt

³Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Alexandra Preisser

⁶Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Matthias Rose

¹⁰Department of Psychosomatic Medicine, Charite University Medical Center, Berlin, Germany

,

Barbara Sawitzky-Rose

¹¹Diabetes Center Berlin Rose, Berlin, Germany

,

Ludger Scheja

⁷Department of Biochjemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Claudia Terschüren

⁶Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Monika Töller

¹²Department of Endocrinology, Diabetology and Rheeumatology, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

,

Eik Vettorazzi

³Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

,

Karl Wegscheider

³Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

› Institutsangaben

Abstract

The Lufthansa Prevention Study (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25–60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history. Psychosocial variables, dietary habits and life-style risk factors were assessed via self-reported questionnaires.

In this report we describe the study design and present baseline parameters including the prevalence of the MetS using different classification criteria. The MetS was present in 20% of male and 12% of female subjects according to the ‘Harmonizing the metabolic syndrome’ definition. The prevalence varies between 2.6% in male and 2.3% in female subjects up to 48% in male and 41% in female subjects according to different classification criteria of MetS.

In conclusion, this first cross-sectional view on the LUPS data confirms the expectation that this cohort is rather healthy and thus provides the opportunity to analyze early changes associated with the development of the MetS. The LUPS study is registered as a clinical trial NCT01313156.

Key words

insulin resistance - nutrition - visceral obesity - dyslipidemia - fasting plasma glucose - depression

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