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Planta Med 2019; 85(03): 239-248
DOI: 10.1055/a-0758-0188
Biological and Pharmacological Activity
Reviews
Georg Thieme Verlag KG Stuttgart · New York

Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives

Anju Benny
Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India
,
Jaya Thomas
Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India
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Publikationsverlauf

received 28. Mai 2018
revised 29. September 2018

accepted 10. Oktober 2018

Publikationsdatum:
25. Oktober 2018 (online)

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Abstract

Alzheimerʼs disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiology. Currently, few drugs are available for the management of Alzheimerʼs disease and the treatment provides only symptomatic relief. Our aim is to review the relevant in vitro, in vivo, and clinical studies focused toward the potential uses of essential oils in the treatment of Alzheimerʼs disease. Scientific databases such as PubMed, ScienceDirect, Scopus, and Google Scholar from April 1998 to June 2018 were explored to collect data. We have conducted wide search on various essential oils used in different models of Alzheimerʼs disease. Out of 55 essential oils identified for Alzheimerʼs intervention, 28 have been included in the present review. A short description of in vivo studies of 13 essential oils together with clinical trial data of Salvia officinalis, Salvia lavandulifolia, Melissa officinalis, Lavandula angustifolia, and Rosmarinus officinalis have been highlighted. In vitro studies of remaining essential oils that possess antioxidant and anticholinesterase potential are also mentioned. Our literary survey revealed encouraging results regarding the various essential oils being studied in preclinical and clinical studies of Alzheimerʼs disease with significant effects in modulating the pathology through anti-amyloid, antioxidants, anticholinesterase, and memory-enhancement activity.

Key words

Alzheimerʼs disease - essential oils - antioxidant - anti-acetylcholinesterase - amyloid β protein
 

  • References

  • 1 Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimerʼs amyloid beta-peptide. Nat Rev Mol Cell Biol 2007; 8: 101-112
    CrossrefPubMedGoogle Scholar
  • 2 Mohandas E, Rajmohan V, Raghunath B. Neurobiology of Alzheimerʼs disease. Indian J Psychiatry 2009; 51: 55-61
    CrossrefPubMedGoogle Scholar
  • 3 Sanabria-Castro A, Alvarado-Echeverria I, Monge-Bonilla C. Molecular pathogenesis of Alzheimerʼs disease: an update. Ann Neurosci 2017; 24: 46-54
    CrossrefPubMedGoogle Scholar
  • 4 Dementia fact sheet Nº 362, 2015. Available at: http://www.WHO.Int/mediacentre/factsheets/fs362/en/ Accessed October 6, 2017
    PubMedGoogle Scholar
  • 5 Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimerʼs disease. Nat Rev Neurol 2011; 7: 137-152
    CrossrefPubMedGoogle Scholar
  • 6 Kumar PS, Karthikeyan S, Iyer PM, Namboori PK. Prediction of epigenetic variations in Alzheimerʼs disease identification of ethnic variants through pharmacogenomic approach. Res J Pharm Biol Chem Sci 2016; 7: 2742-2745
    PubMedGoogle Scholar
  • 7 Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: back to the future. Neuron 2010; 68: 270-281
    CrossrefPubMedGoogle Scholar
  • 8 Hang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012; 148: 1204-1222
    CrossrefPubMedGoogle Scholar
  • 9 Tanzi RE. A brief history of Alzheimerʼs disease gene discovery. J Alzheimers Dis 2013; 33: S5-S13
    PubMedGoogle Scholar
  • 10 Giri M, Zhang M, Lu Y. Genes associated with Alzheimerʼs disease: an overview and current status. Clin Interv Aging 2016; 11: 665-681
    PubMedGoogle Scholar
  • 11 Rocchi A, Orsucci D, Tognoni G, Ceravolo R, Siciliano G. The role of vascular factors in late-onset sporadic Alzheimerʼs disease. Genetic and molecular aspects. Curr Alzheimer Res 2009; 6: 224-237
    CrossrefPubMedGoogle Scholar
  • 12 Stefanova NA, Kolosova NG. Evolution of Alzheimerʼs disease pathogenesis conception. Moscow Univ Biol Sci Bull 2016; 71: 4-10
    CrossrefPubMedGoogle Scholar
  • 13 Mohan CG, Gupta S. QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimerʼs Disease. In: Mohan CG, Gupta S. Oncology: Breakthroughs in Research and Practice. Hershey: IGI Global; 2017: 591-636
    CrossrefGoogle Scholar
  • 14 Roher AE, Kokjohn TA, Clarke SG, Sierks MR, Maarouf CL, Serrano GE, Sabbagh MS, Beach TG. APP/Aβ structural diversity and Alzheimerʼs disease pathogenesis. Neurochem Int 2017; 12: 1-13
    PubMedGoogle Scholar
  • 15 Barage SH, Sonawane KD. Amyloid cascade hypothesis: pathogenesis and therapeutic strategies in Alzheimerʼs disease. Neuropeptides 2015; 52: 1-18
    CrossrefPubMedGoogle Scholar
  • 16 Konrath EL, Passos CD, Klein jr. LC, Henriques AT. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimerʼs disease. J Pharm Pharmacol 2013; 65: 1701-1725
    CrossrefPubMedGoogle Scholar
  • 17 Fotiou D, Kaltsatou A, Tsiptsios D, Nakou M. Evaluation of the cholinergic hypothesis in Alzheimerʼs disease with neuropsychological methods. Aging Clin Exp Res 2015; 27: 727-733
    CrossrefPubMedGoogle Scholar
  • 18 Craig LA, Hong NS, McDonald RJ. Revisiting the cholinergic hypothesis in the development of AD. Neurosci Biobehav Rev 2011; 35: 1397-1409
    CrossrefPubMedGoogle Scholar
  • 19 Zhao Y, Zhao B. Oxidative stress and the pathogenesis of AD. Oxid Med Cell Longev 2013; 2013: 316523
    PubMedGoogle Scholar
  • 20 Wojtunik-Kulesza KA, Oniszczuk A, Oniszczuk T, Waksmundzka-Hajnos M. The influence of common free radicals and antioxidants on development of Alzheimerʼs disease. Biomed Pharmacother 2016; 78: 39-49
    CrossrefPubMedGoogle Scholar
  • 21 Hong-Qi Y, Zhi-Kun S, Sheng-Di C. Current advances in the treatment of Alzheimerʼs disease: focused on considerations targeting Aβ and tau. Transl Neurodegener 2012; 1: 21
    CrossrefPubMedGoogle Scholar
  • 22 Alcolea-Palafox M, Posada-Moreno P, Ortuno-Soriano I, Pacheco-del-Cerro J, Martinez-Rincon C. Research Strategies developed for the Treatment of Alzheimerʼs Disease. Reversible and pseudo-irreversible Inhibitors of Acetylcholinesterase: Structure-activity Relationships and Drug Design. In: Atta-ur-Rahman. Choudhary MI. eds. Drug Design and Discovery in Alzheimerʼs Disease. Amsterdam: Elsevier; 2015: 426-477
    Google Scholar
  • 23 Mehta M, Adem A, Sabbagh M. New acetylcholinesterase inhibitors for Alzheimerʼs disease. Int J Alzheimers Dis 2012; 2012: 728983
    PubMedGoogle Scholar
  • 24 Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J. Neuroprotective and anti-aging potentials of essential oils from aromatic and medicinal plants. Front Aging Neurosci 2017; 9: 168
    CrossrefPubMedGoogle Scholar
  • 25 Tongnuanchan P, Benjakul S. Essential oils: extraction, bioactivities and their uses for food preservation. J Food Sci Tech 2017; 79: R1231-R1249
    PubMedGoogle Scholar
  • 26 Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res 2017; 21: 308-323
    PubMedGoogle Scholar
  • 27 Dobetsberger C, Buchbauer G. Actions of essential oils on the central nervous system: an updated review. Flavour Fragr 2011; 26: 300-316
    CrossrefPubMedGoogle Scholar
  • 28 Bhalla Y, Gupta VK, Zaitak V. Anticancer activity of essential oils: a review. J Sci Food Agric 2013; 93: 3643-3653
    CrossrefPubMedGoogle Scholar
  • 29 Cioanca O, Hritcu L, Mihasana M, Trifan A, Hancianu M. Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1–42) rat model of Alzheimerʼs disease. Physiol Behav 2014; 131: 68-74
    CrossrefPubMedGoogle Scholar
  • 30 Mandal S, Manda M. Corriander (Corriandrum sativum L) essential oil: chemical and biological activity. Asian Pac J Trop Biomed 2015; 5: 421-428
    PubMedGoogle Scholar
  • 31 Cioanca O, Hritcu L, Mihasana M, Hancianu M. Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1–42) rat model of Alzheimerʼs disease. Physiol Behav 2013; 120: 193-202
    CrossrefPubMedGoogle Scholar
  • 32 Mehta AK, Halder S, Khanna N, Tandon OP, Sharma KK. The effect of the essential oil of Eugenia caryophyllata in animal models of depression and locomotor activity. Nutr Neurosci 2013; 16: 233-238
    CrossrefPubMedGoogle Scholar
  • 33 Kumar A, Aggrawal A, Pottabathini R, Singh A. Possible neuroprotective mechanisms of clove oil against icv-colchicine induced cognitive dysfunction. Pharmacol Report 2016; 68: 764-772
    PubMedGoogle Scholar
  • 34 Sajed H, Sahebkar A, Iranshahi M. Zataria multiflora Boiss. (Shirazi thyme) – an ancient condiment with modern pharmaceutical uses. J Ethnopharmacol 2013; 145: 686-698
    CrossrefPubMedGoogle Scholar
  • 35 Majlessi N, Choopani S, Kamalinejad M, Azizi Z. Amelioration of amyloid β-induced cognitive deficits by Zataria multiflora Boiss. Essential oil in a rat model of Alzheimerʼs disease. CNS Neurosci Ther 2011; 18: 295-301
    PubMedGoogle Scholar
  • 36 Wei-Ping W, Juan L, Liang-Xiao Z, Ming-Yue Z, Yi-Zeng L. Chemical fingerprinting of Su-He-Xiang Wan and attribution of major characteristic peaks for its quality control by GC-MS. J Cent South Univ 2013; 20: 2115-2123
    CrossrefPubMedGoogle Scholar
  • 37 Koo BS, Lee SI, Ha JH, Lee DU. Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation. Biol Pharm Bull 2004; 27: 515-519
    CrossrefPubMedGoogle Scholar
  • 38 Hong YK, Park SH, Lee S, Hwang S, Lee MJ, Kim D, Lee JH. Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimerʼs disease. J Ethnopharmacol 2011; 134: 1028-1032
    CrossrefPubMedGoogle Scholar
  • 39 Park SH, Lee S, Hoong YK, Hwang S, Lee JH, Bang SM, Kim YK, Koo BS, Lee IS, Cho KS. Suppressive effects of SuHeXiang Wan on amyloid-β42-induced extracellular signal-regulated kinase hyperactivation and glial cell proliferation in a transgenic Drosophila model of Alzheimerʼs disease. Biol Pharm Bull 2013; 36: 390-398
    CrossrefPubMedGoogle Scholar
  • 40 Jeon S, Hur J, Jeong HJ, Koo BS, Pak SK. SuHeXiang Wan essential oil alleviates amyloid beta induced memory impairment through inhibition of tau protein phosphorylation in mice. Am J Chin Med 2011; 39: 917-932
    CrossrefPubMedGoogle Scholar
  • 41 Pavlovic M, Petrovic S, Milenkovic M, Couladis M, Tzakou O, Niketic M. Chemical composition and antimicrobial activity of Anthriscus nemorosa root essential oil. Nat Prod Commun 2011; 6: 271-273
    PubMedGoogle Scholar
  • 42 Bagci E, Aydin E, Ungureanu E, Hritcu L. Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats. Biomed Pharmacother 2016; 84: 1313-1320
    CrossrefPubMedGoogle Scholar
  • 43 Miroddi M, Navarra M, Quattropani MC, Calapai F, Gangemi S, Calapai G. Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimerʼs disease. CNS Neurosci Ther 2014; 20: 485-495
    CrossrefPubMedGoogle Scholar
  • 44 Lopresti AL. Salvia (sage): a review of its potential cognitive-enhancing and protective effects. Drug R D 2017; 17: 53-64
    PubMedGoogle Scholar
  • 45 Moss L, Rouse M, Wesnes KA, Moss M. Differential effects of the aromas of Salvia species on memory and mood. Hum Psycho Pharmacol Clin Exp 2010; 25: 388-396
    PubMedGoogle Scholar
  • 46 Adam K, Sivropoulou A, Kokkini S, Lanaras T, Arsenakis M. Antifungal activities of Origanum vulgare subsp. Hirtum, Mentha spicata, Lavandula angustifolia and Salvia fruticosa essential oils against human pathogenic fungi. J Agric Food Chem 1998; 46: 1739-1749
    CrossrefPubMedGoogle Scholar
  • 47 Perry NS, Houghton PJ, Sampson J, Theobald AE, Hart S, Lis-Balchin M. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimerʼs disease. J Pharm Pharmacol 2011; 53: 1347-1356
    PubMedGoogle Scholar
  • 48 Perry NS, Houghton PJ, Theobald AE, Jenner P, Perry EK. In-vitro inhibition of erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 2000; 52: 895-902
    CrossrefPubMedGoogle Scholar
  • 49 Perry NS, Houghton PJ, Jenner P, Keith A, Perry EK. Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo . Phytomedicine 2002; 29: 48-51
    PubMedGoogle Scholar
  • 50 Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey AB. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 2003; 75: 669-674
    CrossrefPubMedGoogle Scholar
  • 51 Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2013; 75: 651-659
    PubMedGoogle Scholar
  • 52 Ghaffariyan S, Mohammadi SA, Aharizad S. DNA isolation protocol for the medicinal plant lemon balm (Melissa officinalis, Lamiaceae). Genet Mol Res 2012; 11: 1049-1057
    CrossrefPubMedGoogle Scholar
  • 53 Chung MJ. Anti-diabetic effects of lemon balm (Melissa officinalis) essential oil on glucose and lipid-regulating enzymes in type 2 diabetic mice. Br J Nutr 2010; 104: 180-188
    CrossrefPubMedGoogle Scholar
  • 54 Ballard CG, OʼBrein JT, Reichelt K, Perry EK. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind placebo-controlled trial with Melissa . J Clin Psychiatry 2002; 63: 553-558
    CrossrefPubMedGoogle Scholar
  • 55 Burns A, Perry E, Holmes C, Francis P, Morris J, Howes MJ, Chazot P, Lees G, Ballard C. A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimerʼs disease. Dement Geriatr Cogn Disord 2012; 31: 158-164
    PubMedGoogle Scholar
  • 56 Huang L, Abuhamdah S, Howes MJ, Elliot M, Ballard C, Holmes C. Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. J Pharm Pharmacol 2008; 60: 1515-1522
    CrossrefPubMedGoogle Scholar
  • 57 Elliott MS, Abuhamdah S, Howes MJR, Francis PT. The essential oils from Melissa officinalis L. and Lavandula angustifolia Mill as potential treatment for agitation in people with severe dementia. Int J Essent Oil Ther 2007; 1: 143-152
    PubMedGoogle Scholar
  • 58 Dahmane D, Dob T, Chelghoum C. Chemical composition of essential oils of Juniperus communis L. obtained by hydrodistillation and microwave-assisted hydrodistillation. J Matter Environ Sci 2015; 6: 1253-1259
    PubMedGoogle Scholar
  • 59 Cioanca O, Mircea C, Trifan A, Aprotosoaie AC, Hritcu L, Hancianu M. Improvement of amyloid-β-induced memory deficits by Juniperus communis L. Volatile oil in a rat model of Alzheimerʼs disease. Farmacia 2014; 62: 514-520
    PubMedGoogle Scholar
  • 60 Cioanca O, Hancianu M, Mihasan M, Hritcu L. Anti-acetylcholinesterase and antioxidant activities of inhaled juniper oil on amyloid beta (1–42)-induced oxidative stress. Neurochem Res 2015; 40: 952-960
    CrossrefPubMedGoogle Scholar
  • 61 Fernando WM, Martins IJ, Goozee KG, Brennan CS, Jayasena V, Martins RN. The role of dietary coconut for the prevention and treatment of Alzheimerʼs disease: potential mechanisms of action. Br J Nutr 2015; 114: 1-14
    PubMedGoogle Scholar
  • 62 Hu Yang I, De Ia Rubia Orti JE, Selvi Sabater P, Sancho Castillo S, Rochina MJ, Manresa Ramon N, Montoya-Castillla I. [Coconut oil: nonalternative drug treatment against Alzheimerʼs disease]. Nutr Hosp 2015; 32: 2822-2827
    PubMedGoogle Scholar
  • 63 Nafar F, Clarke JP, Mearow KM. Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways. Neurochem Int 2017; 105: 64-79
    CrossrefPubMedGoogle Scholar
  • 64 Tabanca N, Demirci B, Kirimer N, Baser KH, Bedir E, Khan IA, Wedge DE. Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella aurea, Pimpinella corymbosa, Pimpinella peregrina and Pimpinella puberula gathered from Eastern and Southern Turkey. J Chromatogr A 2005; 1097: 192-198
    CrossrefPubMedGoogle Scholar
  • 65 Aydin E, Hritcu L, Dogan G, Hayta S, Bagci E. The effects of inhaled Pimpinella peregrina essential oil on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Mol Neurobiol 2016; 53: 6557-6567
    CrossrefPubMedGoogle Scholar
  • 66 Jianu C, Pop G, Gruia AT, Horhat FG. Chemical composition and antimicrobial activity of essential oils of lavender (Lavandula angustifolia) and lavandin (Lavandula x intermedia) grown in Western Romania. Int J Agric Biol 2013; 15: 772-776
    PubMedGoogle Scholar
  • 67 Hui L, He L, Huan L, XiaoLan L, AiGuo Z. Chemical composition of lavender essential oil and its antioxidant activity and inhibition against rhinitis related bacteria. Afr J Microbiol Res 2010; 4: 309-313
    PubMedGoogle Scholar
  • 68 Lin PW, Chan WC, Ng BF, Lam LC. Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviors in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry 2007; 22: 405-410
    CrossrefPubMedGoogle Scholar
  • 69 Hritcu L, Cioanca O, Hancianu M. Effect of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats. Phytomedicine 2012; 19: 529-534
    CrossrefPubMedGoogle Scholar
  • 70 Moss M, Cook J, Wesnes K, Duckett P. Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. Int J Neurosci 2003; 113: 15-38
    CrossrefPubMedGoogle Scholar
  • 71 Jimbo D, Kimura V, Taniguchi M, Inour M, Urakami K. Effect of aromatherapy on patients with Alzheimerʼs disease. Psychogeriatrics 2009; 9: 173-179
    CrossrefPubMedGoogle Scholar
  • 72 Takayama C, de-Faria FM, de Almeida ACA, Dunder RJ, Manzo LP, Socca EAR. Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat. Asian Pac J Trop Biomed 2016; 6: 677-681
    CrossrefPubMedGoogle Scholar
  • 73 Sayorwan W, Ruangrungsi N, Piriyapunyporn T, Hongratanaworakit T, Naiphinich Kotchabhakdi N, Siripornpanich V. Effects of inhaled rosemary oil on subjective feelings and activities of the nervous system. Sci Pharm 2013; 81: 531-542
    CrossrefPubMedGoogle Scholar
  • 74 Stefanovits-Banyai E, Tulok MH, Hegedus A, Renner C, Varga IS. Antioxidant effect of various rosemary (Rosmarinus officinalis L.) clones. Acta Biologica Szegediensis 2003; 47: 111-113
    PubMedGoogle Scholar
  • 75 Satou T, Hanashima Y, Mizutani I, Koike K. The effect of inhalation of essential oil from Rosmarinus officinalis on scopolamine-induced Alzheimerʼs type dementia model in mice. Flavour Fragr J 2017; 33: 1-5
    PubMedGoogle Scholar
  • 76 Asadi F, Farahani FK. Effect of essential oil of leaf and aerial part of Rosmarinus Officinalis on passive avoidance memory in aged and young mice. J Alzheimers Dis Parkinsonism 2017; 7 (Suppl.) 6
    PubMedGoogle Scholar
  • 77 Filiptsova OV, Gazzavi-Rogozina LV, Timoshyna IA, Naboka OI, Dyomina YV, Ochkur AV. The effect of the essential oils of lavender and rosemary on the human short-term memory. Alexandria J Med 2018; 54: 41-44
    PubMedGoogle Scholar
  • 78 Moss M, Oliver L. Plasma 1, 8-cineole correlates with cognitive performance following exposure to rosemary essential oil aroma. Ther Adv Psychopharmacol 2012; 2: 103-113
    CrossrefPubMedGoogle Scholar
  • 79 Ayaz M, Junaid M, Ullah F, Sadiq A, Khan MA, Ahmad W. Comparative chemical profiling, cholinesterase inhibitions and antiradicals properties of essential oils from Polygonum hydropiper L: a preliminary anti-Alzheimerʼs study. Lipids Health Dis 2015; 14: 141
    CrossrefPubMedGoogle Scholar
  • 80 Ahmad S, Ullah F, Sadiq A, Ayaz M, Imran M, Ali M. Chemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan. Complement Altern Med 2016; 16: 29
    PubMedGoogle Scholar
  • 81 Tel G, Ozturk M, Duru ME, Harmandar M, Topcu G. Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. Food Chem Toxicol 2010; 48: 3189-3193
    CrossrefPubMedGoogle Scholar
  • 82 Mukherjee PK, Kumar V, Mal M, Houghton PJ. In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents. Planta Med 2010; 73: 283-285
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 83 Erta A, Goern AC, Boga M, Yesil Y, Kolak U. Essential oil compositions and anticholinesterase activities of two edible plants Tragopogon latifolius var. angustifolius and Lycopsis orientalis . Nat Prod Res 2014; 28: 1405-1408
    CrossrefPubMedGoogle Scholar
  • 84 Miyazaw M, Nakahashi H, Usami A, Matsuda N. Chemical composition, aroma evaluation, and inhibitory activity towards acetylcholinesterase of essential oils from Gynura bicolor DC. J Nat Med 2010; 70: 282-289
    PubMedGoogle Scholar
  • 85 Petrovic GM, Stamenkovic JG, Kostevskia IR, Stojanovica GS, Mitica VD, Zlatkovic BK. Chemical composition of volatiles; antimicrobial, antioxidant and cholinesterase inhibitory activity of Chaerophyllum aromaticum L. (Apiaceae) essential oils and extracts. Chem Biodivers 2017; DOI: 10.1002/cbdv.201600367.
    CrossrefPubMedGoogle Scholar
  • 86 Bonesi M, Menichini F, Tundis R, Loizzo MR, Conforti F, Passalacqua NG, Statti GA, Menichini F. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents. J Enzyme Inhib Med Chem 2010; 25: 622-628
    CrossrefPubMedGoogle Scholar
  • 87 Loizzo MR, Jemia MB, Senatore F, Bruno M, Menichini F, Tundis R. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils. Food Chem Toxicol 2013; 259: 586-594
    PubMedGoogle Scholar
  • 88 Aazza S, Lyoussi B, Miguel MG. Antioxidant and anti-acetylcholinesterase activities of some commercial essential oils and their major compounds. Molecules 2011; 16: 7672-7690
    CrossrefPubMedGoogle Scholar
  • 89 Ali B, Al-Wabel NA, Shams S, Ahamad A, Alam Khan S, Anwar F. Essential oils used in aromatherapy: A systematic review. Asian Pacific J Trop Biomed 2015; 5: 601-611
    CrossrefPubMedGoogle Scholar