CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(11): E1349-E1354
DOI: 10.1055/a-0743-5283
Original article
Owner and Copyright © Georg Thieme Verlag KG 2018

Peroral cholangioscopy by SpyGlass DS versus CHF-B260 for evaluation of the lateral spread of extrahepatic cholangiocarcinoma

Yoshihide Kanno
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Shinsuke Koshita
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Takahisa Ogawa
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Kaori Masu
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Hiroaki Kusunose
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Toshitaka Sakai
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Toji Murabayashi
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Sho Haegawa
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Fumisato Kozakai
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Keisuke Yonamine
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Yujiro Kawakami
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Yuki Fujii
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Jun Horaguchi
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
2  Natori Chuo Clinic – Gastroenterology, Natori, Japan
,
Yutaka Noda
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
,
Kei Ito
1  Sendai City Medical Center – Gastroenterology, Sendai, Japan
› Author Affiliations
TRIAL REGISTRATION: Single-center, non-randomized, retrospective study UMIN000030583 at clinicaltrials.gov
Further Information

Publication History

submitted 08 March 2018

accepted after revision 24 July 2018

Publication Date:
07 November 2018 (online)

  

Abstract

Background and study aims A newly developed peroral cholangioscopy (POCS) system, SpyGlassDS has high maneuverability. This study aimed to evaluate acceptability of the accuracy of SpyGlassDS accompanied by simultaneous POCS-guided biopsy compared with that of a traditional POCS scope, CHF-B260, to diagnose the lateral extent of extrahepatic cholangiocarcinoma (LEC).

Patients and methods Patients who underwent surgical resection after preoperative examinations to diagnose LEC were evaluated. POCS by CHF-B260 was performed if there was discrepancy between preceding fluoroscopy-guided biopsy findings and other examinations between January 2004 and September 2015 (group A, n = 56); and POCS plus POCS-guided mapping biopsy by SpyGlassDS was performed in all surgical candidates between October 2015 and December 2017 (group B, n = 20). The main outcome measure was the accuracy of overall preoperative diagnosis (OPD) of LEC defined based on all examinations, including POCS.

Results Accuracy of OPD for the liver side and the ampullary side was 93 % and 100 %, respectively, in group A, and 84 % and 100 %, respectively, in group B (P = 0.37 for the liver side; P, not available for the ampullary side). Diagnostic accuracy of simple optical evaluation by POCS for the liver side and the ampullary side was 83 % and 100 %, respectively, in group A, and 58 % and 88 %, respectively, in group B (P = 0.29 for the liver side; P = 0.40 for the ampullary side).

Conclusions POCS by SpyGlassDS was found to be acceptable and could be a standard approach for diagnosis of LEC.