CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(11): E1363-E1368
DOI: 10.1055/a-0732-494
Original article
Owner and Copyright © Georg Thieme Verlag KG 2018

Booster medication to achieve capsule excretion in colon capsule endoscopy: a randomized controlled trial of three regimens

Rasmus Kroijer
1  Department of Surgery, Odense University Hospital, Odense, Denmark
2  Department of Clinical Science, University of Southern Denmark, Denmark
,
Anne-Kirstine Dyrvig
1  Department of Surgery, Odense University Hospital, Odense, Denmark
3  Odense Patient Data Explorative Network OPEN, University of Southern Denmark, Odense, Denmark
,
Morten Kobaek-Larsen
1  Department of Surgery, Odense University Hospital, Odense, Denmark
2  Department of Clinical Science, University of Southern Denmark, Denmark
,
Jens Overgaard Støvring
4  Department of Surgery, Hospital South West Jutland, Esbjerg, Denmark
,
Niels Qvist
1  Department of Surgery, Odense University Hospital, Odense, Denmark
2  Department of Clinical Science, University of Southern Denmark, Denmark
,
Gunnar Baatrup
1  Department of Surgery, Odense University Hospital, Odense, Denmark
2  Department of Clinical Science, University of Southern Denmark, Denmark
› Author Affiliations
Further Information

Publication History

submitted 11 April 2018

accepted after revision 31 July 2018

Publication Date:
07 November 2018 (online)

  

Abstract

Background and study aims To achieve a complete colon capsule endoscopy, the entire colon must be visualized, clean and filled with clear fluids. The primary aim was to compare three booster regimens in colon capsule endoscopy in achieving capsule excretion within recording time. Secondary aims were quality of bowel cleansing and completion rate (both adequate cleansing and capsule excretion).

Patients and methods Patients scheduled for follow-up colonoscopy due to previous neoplastic findings or familial history of colorectal cancer aged 18 to 70 years were eligible. Bowel preparation was 2-L split doses of polyethylene glycol. Patients were randomized to three booster regimens of either polyethylene glycol (Group A), sulfate-based solution (Group B) or polyethylene glycol with iodine oral contrast (Group C).

Results One hundred eighty participants were included and randomized into three groups of 60. Capsule excretion was 70 % (95 % CI: 58 – 80) in Group A, 73 % (95 % CI: 61 – 83) in Group B and in 68 % (95 % CI: 56 – 79) in Group C, no statistically significant differences. Bowel cleansing grade was statistically significant better in Group B compared to Group A (P = 0.03), but there were no statistically significant differences between Groups C and A (P = 0.40). Complete examination rate was 65 % (95 % CI: 53 – 77), 72 % (95 % CI: 61 – 83) and 62 % (95 % CI: 50 – 74) in Group A, B and C respectively, not statistically significant different.

Conclusions Sulfate-based solution resulted in statistically significant better bowel cleansing compared to polyethylene glycol. Overall the excretion and completion rate was suboptimal. Achieving a high completion rate using patient-tolerable and low-risk compounds is still a challenge.