CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(10): 972-976
DOI: 10.1055/a-0717-5411
GebFra Science
Review
Georg Thieme Verlag KG Stuttgart · New York

Low-grade Serous Ovarian Carcinoma

Low-grade seröse Ovarialkarzinome
Enzo Ricciardi*
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Thaïs Baert*
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
2   Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven, Belgium
,
Beyhan Ataseven
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Florian Heitz
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Sonia Prader
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Mareike Bommert
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Stephanie Schneider
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Andreas du Bois
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
,
Philipp Harter
1   Gynaecology and Gynaecological Oncology, Kliniken Essen-Mitte, Essen, Germany
› Author Affiliations
Further Information

Publication History

received 14 August 2018
revised 24 August 2018

accepted 26 August 2018

Publication Date:
19 October 2018 (online)

Abstract

In the early 2000s a two-tier grading system was introduced for serous ovarian cancer. Since then, we have increasingly come to accept that low-grade serous ovarian carcinoma (LGSOC) is a separate entity with a unique mutational landscape and clinical behaviour. As less than 10% of serous carcinomas of the ovary are low-grade, they are present in only a small number of patients in clinical trials for ovarian cancer. Therefore the current treatment of LGSOC is based on smaller trials, retrospective series, and subgroup analysis of large clinical trials on ovarian cancer. Surgery plays a major role in the treatment of patients with LGSOC. In the systemic treatment of LGSOC, hormonal treatment and targeted therapies seem to play an important role.

Zusammenfassung

Kurz nach der Jahrtausendwende wurde ein 2-stufiges Klassifizierungssystem zur Einstufung von serösen Ovarialkarzinomen eingeführt. Seither wird zunehmend akzeptiert, dass das Low-grade seröse Ovarialkarzinom (LGSOC) eine eigenständige Einheit mit eigener Mutationslandschaft und klinischem Verhalten bildet. Weniger als 10% aller serösen Karzinome des Ovars werden dem Low-Grade-Subtyp zugeordnet, und in den klinischen Studien zum Ovarialkrebs tritt diese Form nur in wenigen Patientinnen auf. Die aktuelle Therapie für das LGSOC basiert daher auf den Ergebnissen kleinerer Studien und retrospektiver Serien sowie auf der Subgruppenanalyse von großen klinischen Studien zum Ovarialkarzinom. Die operative Therapie spielt eine wichtige Rolle für die Behandlung von Patientinnen mit LGSOC. Bei der systemischen Therapie des LGSOC scheinen sowohl hormonelle Therapien als auch gezielte Therapien eine wichtige Rolle zu spielen.

* The authors equally contributed to the paper.


 
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