Schwarzkümmel: Medizin-Tipp aus der Bibel

Zusammenfassung

Seit dem Altertum wird der Schwarzkümmel, auch Gold der Pharaonen genannt, als Heilmittel geschätzt. Der Wirkstoff besitzt vorbeugende und heilende Wirkungen. Verschiedene experimentelle Untersuchungen untermauern die antientzündliche Wirkung. Der Antikrebswirkung liegt eine antiproliferative, proapoptotische, antioxidative, zytotoxische und antimetastatische Wirkung zugrunde. Außerdem stimuliert der Schwarzkümmel-Wirkstoff die Killerzellen im Blut. Wie synthetische Zytostatika wirkt die Leitsubstanz Thymochinon alkylierend. Tierexperimentell besaß der Schwarzkümmel in verschiedenen Modellen eine organprotektive Wirkung und reduzierte den durch Galaktose ausgelösten Alterungsprozess. Schwarzkümmelzubereitungen wirkten u. a. hypoglykämisch, blutdrucksenkend, antiasthmatisch, spasmolytisch, antidepressiv, antimikrobiell, antiviral und antiparasitär. Das präklinische Sicherheitsprofil ist inkomplett. Nach Zufuhr größerer Mengen ist mit toxischen Wirkungen zu rechnen.

Abstract

Black seed, a medical hint from the Bible. Part 1: Pharmacological effects from seeds and seed oil

Since ancient times, black seed (black cumin), also known as „Gold of the Pharaohs“, is a well appreciated remedy due to its prophylactic and curing effects. Various experimental studies indicate anti-inflammatory activities. The anti-cancer activity is based on antiproliferative, pro-apoptotic, anti-oxidative, cytotoxic and anti-metastatic effects. The active principle of black seed also stimulates the natural killer cells in the blood. Similar to synthetic cytostatic chemotherapeutics, the leading compound thymoquinone acts as an alkylating agent. Animal experiments demonstrated organo-protective effects in various test procedures including galactose-induced aging. The black seed active principle decreased elevated blood glucose and blood pressure, acted anti-asthmatic, spasmolytic, antidepressant, antimicrobial, antiviral and antiparasitic. However, the preclinical safety profile is incomplete. Ingestion of higher quantities of black seed may be associated with toxic effects.

Schlüsselwörter

Nigella sativa L. - Schwarzkümmel - Thymochinon - experimentelle Studien - Tierversuche

Key words

Nigella sativa L. - black seed - black cumin - thymoquinone - experimental studies - animal studies

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