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Horm Metab Res 2018; 50(08): 587-596
DOI: 10.1055/a-0651-4842
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Vitamin D Supplementation on Markers Related to Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Reza Tabrizi
1   Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Sina Vakili
2   Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
,
Kamran B. Lankarani
3   Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
,
Maryam Akbari
1   Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Mehri Jamilian
4   Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
,
Zahra Mahdizadeh
5   Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Naghmeh Mirhosseini
6   Pure North S’Energy Foundation, Calgary, AB, Canada
,
Zatollah Asemi
7   Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
› Author Affiliations
Further Information

Publication History

received 31 May 2018

accepted 28 June 2018

Publication Date:
06 August 2018 (online)

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Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to summarize the effect of vitamin D supplementation on endothelial function among people with metabolic syndrome and related disorders. Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published up 20th May 2018. To check heterogeneity a Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Twenty-two trials of 931 potential citations were found to be eligible for current meta-analysis. The pooled findings by using random effects model indicated that vitamin D supplementation to individuals with MetS and related disorders significantly increased flow-mediated dilatation (FMD) (SMD=1.10; 95% CI, 0.38, 1.81, p=0.003). However, it did not affect pulse-wave velocity (PWV) (SMD=0.04; 95% CI, –0.25, 0.33, p=0.80) and augmentation index (AI) (SMD=0.07; 95% CI, –0.25, 0.40; p=0.65). Overall, this meta-analysis demonstrated that vitamin D supplementation to patients with metabolic syndrome and related disorders resulted in an improvement in FMD, but did not influence PWV and AI.

Key words

vitamin D supplementation - endothelial function - metabolic syndrome - meta-analysis

Supplementary Material

 

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