The impact of endoscopic ultrasound-guided fine-needle aspiration of lymph nodes on subsequent positron emission tomography/computed tomography imaging: a prospective study

Ole Steen Bjerring; Søren Hess; Claus Wilki Fristrup; Poul Flemming Høilund-Carlsen; Michael Bau Mortensen

doi:10.1055/a-0647-6824

Endoscopy, Table of Contents

Endoscopy 2019; 51(02): 165-168
DOI: 10.1055/a-0647-6824

Innovations and brief communications

The impact of endoscopic ultrasound-guided fine-needle aspiration of lymph nodes on subsequent positron emission tomography/computed tomography imaging: a prospective study

Authors

Ole Steen Bjerring

¹Department of Surgery, Upper GI Section and Odense Pancreas Center, Odense University Hospital, Odense, Denmark

²Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Søren Hess

²Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

³Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

⁴Department of Radiology and Nuclear Medicine, Hospital of Southwest Jutland, Esbjerg, Denmark
Claus Wilki Fristrup

¹Department of Surgery, Upper GI Section and Odense Pancreas Center, Odense University Hospital, Odense, Denmark

²Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Poul Flemming Høilund-Carlsen

²Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

³Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

⁴Department of Radiology and Nuclear Medicine, Hospital of Southwest Jutland, Esbjerg, Denmark
Michael Bau Mortensen

¹Department of Surgery, Upper GI Section and Odense Pancreas Center, Odense University Hospital, Odense, Denmark

²Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

Abstract

Background Modern cancer diagnostic work-up is based on multiple modalities within a short time period. The interplay between these modalities is complex and not well known. Performing biopsy procedures prior to (18)F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is considered to pose a risk of false-positive imaging results; however, this is not based on solid scientific evidence. The use of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is commonly used in upper gastrointestinal malignancies, is proven safe, and has very little risk of complications. This study aimed to assess whether EUS-FNA induces inflammation that would increase FDG uptake on subsequent PET/CT.

Methods 27 patients who were referred for upper gastrointestinal EUS for different reasons initially underwent FDG-PET/CT to detect biopsy-eligible lymph nodes with no FDG uptake. Patients then underwent EUS-FNA of the benign lymph nodes, with a minimum of three passes. Patients were re-evaluated with FDG-PET/CT 1 week later, with specific emphasis on the biopsied lymph nodes.

Results None of the biopsied lymph nodes showed increased FDG uptake on follow-up FDG-PET/CT. No adverse events occurred.

Conclusion EUS-FNA prior to FDG-PET/CT did not lead to false-positive FDG uptake. The interpretive impact of minor procedures prior to FDG-PET/CT needs to be re-evaluated.

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References

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