Modified Fe3O4/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study

Sarvin Mohammadi-Aghdam; Bahareh Valinezhad-Saghezi; Yousef Mortazavi; Seyedeh Masoumeh Qhoreishi

doi:10.1055/a-0647-1765

Drug Research, Inhaltsverzeichnis

Drug Res (Stuttg) 2019; 69(02): 93-99
DOI: 10.1055/a-0647-1765

Original Article

Modified Fe₃O₄/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study

Authors

Sarvin Mohammadi-Aghdam

¹Department of Chemistry, Payame Noor University, Tehran, Iran
Bahareh Valinezhad-Saghezi

²College of Chemistry, University of Kurdistan, Kurdistan, Iran.
Yousef Mortazavi

³Pramedicine Faculty, Anesthesiology and Operation Department, Babol University of Medical Sciences, Babol, Iran
Seyedeh Masoumeh Qhoreishi

⁴Cellular and Molecular Biology Research Center, Health Research Institue, Babol University of Medical Science, Babol, Iran

Abstract

The adsorption capacity and release attributes of magnetic Fe₃O₄@hydroxyapatite (Fe₃O₄/HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe₃O₄@hydroxyapatite and functionalized Fe₃O₄@hydroxyapatite) were then conducted. The characteristic of the obtained materials was performed with X-ray-diffraction (XRD), energy dispersive X-ray microanalysis (EDS), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-Vis analysis, vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). Results show that functionalized magnetic Fe₃O₄@hydroxyapatite nanoparticles leads than a substantial decrease of the drug delivery rate in pH=6.8 after investigated drug release in intestine environment. In addition, the results demonstrate that high adsorption capacity for drug and slower drug release rate was obtained after functionalized nanoparticles than Fe₃O₄@hydroxyapatite and pure hydroxyapatite.

Key word

Drug delivery - Ibuprofen - APTS - Hydroxyapatite - Scanning electron microscopy

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Referenzen

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