Abstract
The aim of this study was to measure the impact, at 24 h post-exercise, of a single
exercise bout on plasma inflammatory markers such as calprotectin, IL-6, sIL-6 R,
sgp130 and the hypothalamic-pituitary-adrenal (HPA) axis in children with juvenile
idiopathic arthritis (JIA).
Twelve children with JIA attended the laboratory on three consecutive days (control
day, exercise day and 24 h post-exercise), including a 20-min exercise bout on a cycle-ergometer
at 70% of max. HR at 8:30 a.m. on day 2. Plasma concentrations of calprotectin, IL-6,
sIL-6 R, sgp130, cortisol, ACTH and DHEA were measured on venous blood samples taken
every day.at rest and at 8:30, 8:50, 9:30, 10:30 a.m. and 12:00, 3:00, 5:30 p.m.
A single exercise bout increased plasma calprotectin 1.7-fold (p<0.001) but did not
increase IL-6 and soluble IL-6 receptors in short-term post-exercise recovery. However,
at 24 h post-exercise, calprotectin, IL-6 and its receptors had decreased compared
to control-day levels. There was a transient 2-fold increase in post-exercise self-evaluated
pain (p=0.03) that disappeared in the evening without repercussions the following
day.
Physical activity in children with JIA results in a slight transient systemic inflammation
but seems to be followed by counter-regulation at 24 h post-exercise with a decrease
in proinflammatory markers.
Key words
pediatric - physical activity - S100A8/A9 - IL-6 - sgp130 - sIL-6 R