Horm Metab Res 2018; 50(07): 521-536
DOI: 10.1055/a-0637-1975
Review
© Georg Thieme Verlag KG Stuttgart · New York

Correlation Between Resistin Level and Metabolic Syndrome Component: A Review

Mostafa Mostafazadeh
1  Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2  Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran
,
Sanya Haiaty
3  Infectious and Tropical Diseases Research Center, Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran
,
Ali Rastqar
4  Department de Psychiatry et Neuroscience, Université Laval, Québec, QC, Canada
5  Centre Hospitalier de l’Université Laval (CHUL), Québec, QC, Canada
,
Mahtab Keshvari
6  Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of medical Sciences, Isfahan, Iran
› Author Affiliations
Further Information

Publication History

received 01 February 2018

accepted 22 May 2018

Publication Date:
10 July 2018 (online)

Abstract

Metabolic syndrome (MetS) has a collection of some abnormal and pathological conditions that cause many critical diseases. Resistin is one of the possible candidates for these pathologies but there are not enough data to prove if resistin has positive, neutral, or negative effects on one or some components of MetS. This review summarizes data about comparing the effects and contribution of resistin in initiation and progression of MetS components and also its different actions between human and other mammalians. This summarized data about the relationship of resistin and MetS components have been obtained from clinical researches and in some cases even animal studies. To find the relevant studies, the search in PubMed, Science Direct, and Scopus were performed. Human and animal studies on relationships between resistin and MetS (initiation and progression of components) were included in our search. In experiments reported among different human genetic groups as well as the patients with various disease such as diabetes, no significant correlation is shown between FBG and resistin level. Furthermore, this review shows that the results of correlation between resistin and TG, HDL, and central or abdominal obesity were inconsistent. These inconsistencies can arise from different sample size or genetic groups, gender, and also from experimental studies. Therefore, to obtain precise results systematic review and meta-analyses are required.