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Int J Sports Med 2018; 39(13): 1028-1034
DOI: 10.1055/a-0634-6387
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Association of Monocarboxylate Transporter-1 (MCT1) A1470T Polymorphism (rs1049434) with Forward Football Player Status.

Myosotis Massidda
1   Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy
2   Italian Sports Medicine Federation (FMSI), Rome, Italy
,
Alberto Mendez-Villanueva
3   ASPIRE Academy for Sports Excellence, Doha, Qatar
,
Valentina Ginevičienė
4   Vilnius University, Department of Human and Medical Genetics, Vilnus, Lithuania
,
Patrizia Proia
5   Department of Psychological, Pedagogical and Educational Sciences, Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, Italy
,
Svitlana B. Drozdovska
6   National University of Physical Education and Sports of Ukraine, Kiev, Ukraine
,
Victor Dosenko
7   Bogomoletz Institute of Physiology, National Academy of Science, Kiev, Ukraine
,
Marco Scorcu
2   Italian Sports Medicine Federation (FMSI), Rome, Italy
8   Cagliari Calcio Spa, Cagliari, Italy
,
Aleksander Stula
9   Faculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland
,
Marek Sawczuk
10   Department of Tourism and Recreation, University of Physical Education and Sport, Gdańsk, Poland
,
Paweł Cięszczyk   *
11   Department of Physical Education, University of Physical Education and Sport, Gdańsk, Poland.
,
Carla Maria Calò   *
1   Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy
› Author Affiliations
Further Information

Publication History



accepted 17 May 2018

Publication Date:
05 October 2018 (online)

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Abstract

The aim of this study was to investigate the association between the MCT1 (monocarboxylate transporter 1) A1470T polymorphism and positional roles in a large cohort of professional football players from five different countries. We compared genotype distributions of the MCT1 A1470T polymorphism between football players (n=694) and non-athlete controls (n=781) from Italy, Poland, Lithuania, Ukraine and Malta, and we analyzed the MCT1 genotype distributions with respect to the players’ positions in the field (e. g. forwards, midfielders, defenders and goalkeepers). Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. In the pooled cohort of Italian, Polish, Lithuanian and Ukrainian football players, forwards (n=148) were more likely than controls (n=781) to possess the A allele (χ2=7.067, p=0.029, FDR q value 0.116), with a greater likelihood of having the AA genotype compared with the TT genotype (OR=1.97; C.I.=1.07-3.64; p=0.021, FDR q value 0.086). The MCT1 AA genotype was significantly more frequent in forwards then in controls. Further studies are needed to confirm these findings in other professional football player cohorts.

Key words

genetic differences - lactate - monocarboxylate transporter-1 - repeated sprint ability - soccer

* Carla Maria Calò and Pawel Cieszczyk are equally contributing authors.


 

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