CC BY-NC-ND 4.0 · PMIO 2018; 5(02): e48-e54
DOI: 10.1055/a-0600-9786
Original Papers
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Anti-inflammatory Effects of Distylium racemosum Extract in a Mouse Model of Allergic Asthma

Jong-Heon Han*
Bio Convergence Center, Jeju Technopark, Jeju, Korea
,
Kyuhee Park*
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Jong Suk Lee
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Yeon-Ju Nam
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Jungeun Yang
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Myung-Jin Song
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
,
Sung-Jin Ko
Bio Convergence Center, Jeju Technopark, Jeju, Korea
,
Su-Gyeong Kim
Bio Convergence Center, Jeju Technopark, Jeju, Korea
,
Hoo-Dhon Byun
Bio Convergence Center, Jeju Technopark, Jeju, Korea
,
Young Ho Kim
College of Pharmacy, Chungnam National University, Daejon, Korea
,
Ji-Gweon Park
Bio Convergence Center, Jeju Technopark, Jeju, Korea
,
Yongmun Choi
Biocenter, Gyeonggido Business and Science Accelerator, Suwon, Korea
› Author Affiliations
Further Information

Publication History

received 18 January 2018
revised 11 March 2018

accepted 22 March 2018

Publication Date:
28 May 2018 (online)

Abstract

Allergic asthma is a complex disorder characterized by chronic airway inflammation. Patients with asthma often show poor adherence to corticosteroid therapy owing to prominent side effects, which provides a rationale to explore new drug classes with a better safety profile. In this study, we sought to discover natural products that inhibit the activity of phosphodiesterase 4, which is considered a potential molecular target for anti-inflammatory therapy. The screening of a plant extract library led to the identification of Distylium racemosum, which inhibited phosphodiesterase 4 activity in vitro and suppressed lipopolysaccharide-induced inflammatory signaling in cultured cells. In a mouse model of ovalbumin-induced allergic asthma, D. racemosum treatment significantly reduced inflammatory responses in the lung, as well as serum immunoglobulin E levels. Although the active constituents of D. racemosum extract and the exact mechanism underlying the in vivo action of D. racemosum remain to be elucidated, our results provide a basis for further investigation of D. racemosum extract as a novel anti-inflammatory agent for allergic asthma.

* These authors contributed equally to this work.