Verzögerte Kohlenmonoxidenzephalopathie

Zusammenfassung

Kohlenmonoxid-Vergiftungen sind weltweit häufige Intoxikationen, bei denen das Spektrum der Symptome von leichten Kopfschmerzen und Schwindel bis hin zum Tod reicht. Wenig bekannt ist die verzögerte Kohlenmonoxidenzephalopathie, die mit einer Latenz von 2–40 Tagen nach dem Initialereignis auftreten kann. Häufige klinische Manifestationen sind dabei Bewegungsstörungen, kognitive- oder affektive Störungen. Dieser Artikel beschreibt exemplarisch den Fall eines Patienten mit einer akzidentellen Kohlenmonoxidvergiftung mit verzögert auftretender Enzephalopathie. In der anschließenden Übersichtsarbeit wird die Literatur hinsichtlich Klinik, Diagnostik, Pathophysiologie und Therapieoptionen zusammengefasst.

Abstract

Carbon monoxide poisoning is a very common intoxication worldwide. Its clinical manifestations vary from symptoms like mild headache and dizziness to more serious issues including death. Less well known are symptoms that occur with a delay of 2–40 days, such as movement disorders, cognitive impairment or affective disorders. In this article, we present a case of carbon monoxide poisoning with a delayed neurological sequela. The following review summarizes the literature on clinical presentation, diagnostic options, pathophysiology and therapy of this disease.

Schlüsselwörter

Kohlenmonoxid - Intoxikation - Enzephalopathie - Hämorrhagische Nekrose

Key words

Carbon monoxide - Poisoning - Neurological sequelae - Hemorrhagic necrosis

• Literatur

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