CC BY-NC-ND 4.0 · Ultrasound Int Open 2018; 04(02): E45-E51
DOI: 10.1055/a-0591-6070
Original Article
Eigentümer und Copyright ©Georg Thieme Verlag KG 2018

Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type

Kaoru Kobayashi
1  Department of Surgery, Kuma Hospital, Kobe, Japan
,
Tomoko Fujimoto
2  Department of Clinical Laboratory, Kuma Byoin, Kobe, Japan
,
Hisashi Ota
2  Department of Clinical Laboratory, Kuma Byoin, Kobe, Japan
,
Mitsuyoshi Hirokawa
3  Department of Diagnostic Pathology, Kuma Hospital, Kobe, Japan
,
Tomonori Yabuta
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Hiroo Masuoka
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Mitsuhiro Fukushima
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Takuya Higashiyama
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Minoru Kihara
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Yasuhiro Ito
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Akihiro Miya
4  Department of Surgery, Kuma Byoin, Kobe, Japan
,
Akira Miyauchi
4  Department of Surgery, Kuma Byoin, Kobe, Japan
› Author Affiliations
Further Information

Publication History

received 04 October 2017
revised 19 February 2018

accepted 05 March 2018

Publication Date:
05 July 2018 (online)

Abstract

Purpose

The purpose of the study is to clarify the prevalence of calcifications within thyroid tumors on ultrasonography as well as the relationship between the calcification and histopathological types.

Materials and Methods

Calcifications were classified into 6 (or 8) types according to their shape, size, and region. The prevalence of calcifications and types were investigated in new outpatients and patients who underwent thyroid surgery.

Results

Among 2,902 nodules in 2,678 new outpatients, 747 nodules (26%) had calcifications. The types showed a wide distribution. Among 941 patients with papillary carcinoma (PC), 725 patients (77%) had calcifications, and the types showed a wide distribution. 18 patients with the diffuse sclerosing variant of PC only showed punctate microcalcifications in the parenchyma (100%), 32 patients with the cyst-forming type of PC mostly fragmentary and massive types (100%), and 161 metastatic lymph nodes from PC mostly punctate microcalcifications and fragmentary types (48%). Among 337 patients with follicular carcinoma, 79 patients (23%) had calcifications, and the types were mostly fragmentary, massive, and egg-shell types. Among 41 patients with undifferentiated carcinoma, 33 patients (80%) presented with calcifications, which were mostly the massive and egg-shell types. Among 137 patients with medullary carcinoma, 99 patients (72%) had calcification, and the types showed a wide distribution. None of 173 patients with primary thyroid lymphoma had calcifications (0%).

Conclusion

Calcifications on ultrasonography can be one of the characteristic findings and a full understanding of the prevalence of calcifications and types will markedly contribute to the ultrasonic diagnosis of thyroid tumors.