Drug Res (Stuttg) 2018; 68(10): 576-583
DOI: 10.1055/a-0591-2506
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Nanocrystalization of Pioglitazone by Precipitation Method

Jaleh Varshosaz
1   Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
,
Saeedeh Ahmadipour
1   Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
,
Majid Tabbakhian
1   Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
,
Shokoufeh Ahmadipour
2   Faculty of medicine, Department of Pediatric, Lorestan University of medical Sciences, Khorramabad, Iran
› Author Affiliations
Further Information

Publication History

received 31 December 2017

accepted 09 March 2018

Publication Date:
09 April 2018 (online)

Abstract

Background Poor solubility in aqueous medium limits the use of many drugs. Different methods have been adopted to promote the rate of dissolution of slightly water soluble drugs. Crystallization improves solubility, and bioavailability by increasing the surface area of slightly water soluble drugs. Pioglitazone (PGZ), which is a class II Biopharmaceutical Classification System drug has a slight solubility in water and a slow rate of dissolution, which may have a negative effect on its metabolism leading to a therapeutic failure.

Aim The aim of this study was to improve the solubility of PGZ-HCl; an antidiabetic drug using precipitation method.

Materials and Methods Formulations were prepared with polyethylene glycol 6000 and isomalt using different speed of homogenizer and quantity of solvent by precipitation method. Drug-polymer interactions were examined using differential scanning calorimetry (DSC), and Powder X-Ray Diffraction (PXRD). Surface structure were shown by SEM photographs.

Results The particle size was significantly decreased and solubility was enhanced with increase speed, ethanol solvent and increase stabilizer, however very high amount of stabilizer resulted in a decrease in solubility.

Conclusion This result however showed that solid dispersion technique is a potential method for increasing dissolution profile of a poorly aqueous soluble agent.