CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(06): E646-E651
DOI: 10.1055/a-0581-8758
Original article
Owner and Copyright © Georg Thieme Verlag KG 2018

Development and validation of a computed assessment of cleansing score for evaluation of quality of small-bowel visualization in capsule endoscopy

Einas Abou Ali
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
,
Aymeric Histace
ETIS UMR 8051, University Paris-Seine, University of Cergy-Pontoise, ENSEA, CNRS, Cergy, France
,
Marine Camus
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
Sorbonne University, Paris, France
,
Rafaële Gerometta
Saint Joseph Hospital, Paris, France
,
Aymeric Becq
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
Sorbonne University, Paris, France
,
Olivia Pietri
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
Sorbonne University, Paris, France
,
Isabelle Nion-Larmurier
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
,
Cynthia Li
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
College of Arts and Sciences, Drexel University, Philadelphia, Pennsylvania, United States
,
Ulriikka Chaput
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
,
Philippe Marteau
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
Sorbonne University, Paris, France
,
Christian Florent
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
Sorbonne University, Paris, France
,
Xavier Dray
Saint-Antoine Hospital, AP-HP, Department of Hepatogastroenterology, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
ETIS UMR 8051, University Paris-Seine, University of Cergy-Pontoise, ENSEA, CNRS, Cergy, France
Sorbonne University, Paris, France
› Author Affiliations
Further Information

Publication History

submitted 12 August 2017

accepted after revision 25 January 2018

Publication Date:
25 May 2018 (online)

Abstract

Background and study aims An objective and reliable scoring system is needed to assess quality of visualization in small bowel (SB) capsule endoscopy (CE), for both clinical practice and research purposes. The aim of this study was to establish and to validate a SB-computed assessment of cleansing (SB-CAC) score.

Patients and methods Thirty-three SB-CE were selected. A CAC score, defined as the ratio of the red over green pixels (R/G ratio), was calculated for each frame. Intervals were then determined, ranging from the lowest to the highest ratio among the extracted frames. Twelve frames were randomly selected in each of these intervals. Two hundred eighty-eight frames were shuffled and analyzed twice in random order by two experienced CE readers who were blinded to the CAC scores. Once an “adequately cleansed” or “inadequately cleansed” qualification was allotted to every still frame, a receiver operating characteristic (ROC) curve was created. In case of discrepancy between the two readers, the still frames were excluded. A second dataset of 288 different SB still frames was generated and read twice in random order by two other experienced SB-CE readers, using the same methodology.

Results A SB-CAC score threshold of 1.6 best achieved discrimination of adequately from inadequately cleansed frames, with a sensitivity of 92.7 % (95 %CI [89.7 – 95.8]) and a specificity of 92.9 % (95 %CI [89.9 – 95.9]). This threshold was validated using the second dataset, yielding the following performances: sensitivity 91.3 % (95 %CI [87.9 – 94.6]), specificity 94.7 % (95 %CI [92.1 – 97.3]).

Conclusion An SB-CAC score of 1.6 has the highest sensitivity and specificity to discriminate “adequately cleansed” from “inadequately cleansed” SB-CE still frames. This constitutes an objective, reproducible, reliable, and automated cleansing score for SB-CE.