Exp Clin Endocrinol Diabetes 2021; 129(01): 56-72
DOI: 10.1055/a-0579-7860
Meta-Analyses

Tolerability and Efficacy of Ipragliflozin in The Management of Inadequately Controlled Type 2 Diabetes mellitus: A Systematic Review and Meta-analysis

Ahmed Elgebaly
1  Medical Research Society, Cairo University, Cairo, Egypt
2  Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
,
Nesrine Abdelazeim
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
,
Bassant Abdelazeim
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
,
Gehad El Ashal
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
,
Omar Mattar
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
,
Lubaba Namous
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
,
Noha Nasreldin
1  Medical Research Society, Cairo University, Cairo, Egypt
3  Kasr-AlAiny Medical School, Cairo University
› Author Affiliations
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Abstract

Aim Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM).

Methods We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5.3 for windows. Subgroup and sensitivity analyses were conducted.

Results We included 13 RCTs (N=2535 patients) in the final analysis. The overall effect estimates favoured ipragliflozin 50mg monotherapy group over placebo in terms of: HbA1c (Standardized mean difference (SMD)=-1.20%, 95% Confidence interval (95% CI)=[-1.47, -0.93]; p<0.001), fasting plasma glucose (SMD=-1.30 mg/dL, 95% CI [−1.93, −0.67]; p<0.001), fasting serum insulin (SMD=−1.64 μU/mL, 95% CI [−2.70, −0.59]; p=0.002), and body weight (SMD=−0.85 kg, 95% CI [−1.19, −0.51]; p<0.001). Similarly, better glycemic control and significant body weight reduction compared to placebo were attained in ipragliflozin 50 mg combination with metformin, insulin with/without dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone. Ipragliflozin, either alone or in combination, exhibits acceptable safety profile.

Conclusion The presented meta-analysis provides class one evidence that ipragliflozin is safe and effective in the management of T2DM either as monotherapy or an add-on.

Supplementary Material



Publication History

Received: 04 October 2017
Received: 09 February 2018

Accepted: 19 February 2018

Publication Date:
18 June 2018 (online)

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