Exp Clin Endocrinol Diabetes 2018; 126(06): 333-341
DOI: 10.1055/a-0577-7574
Review
© Georg Thieme Verlag KG Stuttgart · New York

Amiodarone-Induced Thyroid Dysfunction: A Clinical Update

Mohamed Nabil Elnaggar
1   Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP
4   Internal Medicine Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt
,
Kahtan Jbeili
1   Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP
,
Nik Nik-Hussin
2   Department of Radiology and Nuclear Imaging Services, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP
,
Mohandas Kozhippally
3   Department of Medicine, Good Hope Hospital, Heart of England NHS Foundation Trust, Birmingham, United Kingdom, B75 7RR
,
Joseph M Pappachan
1   Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP
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Publikationsverlauf

received 02. Januar 2018
revised 06. Februar 2018

accepted 11. Februar 2018

Publikationsdatum:
20. März 2018 (online)

Abstract

Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Amiodarone-induced hypothyroidism (AIH) is diagnosed and managed in the same way as a usual case of hypothyroidism. However, differential diagnosis and clinical management of amiodarone-induced thyrotoxicosis (AIT) subtypes can be challenging. With the aid of a case snippet, we update the current evidence for the diagnostic work up and management of patients with amiodarone-induced thyroid dysfunction in this article.