Dtsch Med Wochenschr 2019; 144(04): 264-275
DOI: 10.1055/a-0160-8413
CME-Fortbildung
© Georg Thieme Verlag KG Stuttgart · New York

Arzneimittelinteraktionen, die man kennen muss!

Drug-drug interactions you should know!
Niels Voigt
,
Katharina Ort
,
Samuel Sossalla
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Januar 2019 (online)

Abstract

Drug-drug interactions (DDI) represent a significant problem in modern medicine. The number of patients with multi-morbidity, who take multiple drugs, is constantly increasing (polypharmacy). The related exponential increase in potential DDI is almost incomprehensible. In this article, we review pharmacodynamic DDI and provide clinically relevant examples. In addition, we extensively review pharmakokinetic DDI (e. g. through the cytochrome P450-system or p-glycoproteins) that can modify the plasma concentration of many compounds, thereby also increasing the likelihood of unwanted side effects. Finally we provide tools, which may help clinicians in their daily practice to identify and avoid potential DDI. In the context of an ageing society receiving polypharmacy, a better awareness of DDI and of strategies to prevent them is expected to reduce mortality and morbidity.

Arzneimittelinteraktionen (AMI) sind ein häufig unterschätztes Problem der modernen Medizin. Die Zahl älterer, multimorbider Patienten, die mehrere Wirkstoffe gleichzeitig einnehmen, nimmt stetig zu – der damit verbundene exponentielle Anstieg möglicher AMI ist fast unüberschaubar. Diese Übersicht stellt häufige, relevante AMI anhand von Beispielen dar und zeigt Strategien auf, wie sie in der Praxis frühzeitig erkannt und vermieden werden können.

 
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