Is there scientific evidence that suppression of acute diseases in childhood induce chronic diseases in the future?

Abstract

Seeking to understand the individual in his symptomatic totality has been an aim of homeopathy since its beginning. Throughout its history, homeopaths have been concerned that inadequate treatment of acute diseases in childhood may lead to future chronic diseases. Hahnemann cautioned that by treating acute diseases with allopathic medicine, with strong doses of drugs, or suppressing local symptoms of those diseases, would increase the risk of future chronic diseases. Burnett proposed the theory of vaccinosis and warned of chronic manifestations subsequent to smallpox vaccination. French homeopaths, seeking the physiopathological origin of chronic diseases, correlated it to the abnormal reaction of the reticuloendothelial system (RES). Through the study of experimental pathology, Maffei attributed symptomatic manifestations to the imbalance between the immunological phenomena of allergy and immunity. He termed the sensitizing and pathogenic effects of medications and vaccines, ‘metallergy’ and ‘parallergy’, respectively.

The hygiene hypothesis is based on evidence that the imbalance of immunological response in childhood, specifically among the Th1 and Th2 lymphocyte subpopulations, is responsible for the development of some allergic and chronic diseases in the future. The deranging factor for the predisposition to future allergic response (Th2) is the obstruction of natural manifestations of infectious diseases (Th1 response) in young children. Homeopathic treatment aims to equilibrate vital reaction, corresponding to an integrative physiological response, it may regulate Th1/Th2 imbalance. However, clinical trials to support this hypothesis are lacking.

Keywords

immunization - vaccinosis - hygiene hypothesis - chronic diseases - acute disease suppression

• References

• 1 Hahnemann S. Organon of Medicine. New Delhi: B. Jain Publishers; 1991.
• 2 Hahnemann S. Dudgeon RG. The Chronic Diseases. 1983. New Delhi: B. Jain Publishers;
• 3 Burnett JC. Vaccinosis and its Cure by Thuya; with Remarks on Homeoprophilaxis. Calcuta: Roy Publishing House; 1976.
• 4 Bernard, H, La reticulo-endotheliose chronique ou sycose, Angoulome, Editions Coquemard.
• 5 Bernard H. Doctrine Homeopathique. Angoulome: Editions Coquemard; 1966.
• 6 Selye, H, The physiology and Pathology of Exposure to Stress. General Adaptation—Syndrome and the Diseases of Adaptation, Montreal, Acta Inc. Medical Publishers.
• 7 Husemann, F, Wolff, O, A imagem do homem como base da arte médica: patologia e terapêutica, São Paulo, Editora Resenha Universitária Ltda, 1978.
• 8 Brito GS, Spozatti M CC. Vacinação—Prevenção ou agressão… Onde fica o bom senso. São Paulo: Editorial; Compêndio de Homeopatia. vol III 1997. pp. 279–307.
• 9 Maffei WE. Os Fundamentos da Medicina. São Paulo: Artes Médicas; vol 2 1978. pp. 430–485.
• 10 Pirquet C. Allergie. Berlin: Julius Springer; 1910.
• 11 Kay AB. Asthma and inflamation. J Allergy Clin Immunol 1991; 87: 893-910.
• 12 Ricci M, Rossi O, Bertoni M, Matucci A. The importance of Th-2-like cells in the pathogenesis of airway allergic inflammation. Clin Exp Allergy 1993; 23: 360-369.
• 13 Warner JA, Waarner JO. Early life events in allergic sensitisation. Br Med Bull 2000; 56: 883-893.
• 14 Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259-1260.
• 15 Hertzen LC. The hygiene hypothesis in the development of atopy and asthma—still a matter of controversy?. Q J Med 1998; 91: 767-771.
• 16 Wold AE. The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora?. Allergy 1998; 53 (Suppl. 46) 20-25.
• 17 Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999; 354 (Suppl II): SII12-SII15.
• 18 Kay AB. Overview of allergy and allergic diseases: with a view to the future. Br Med Bull 2000; 56: 843-864.
• 19 Matricardi PM, Bonini S. High microbial turnover rate preventing atopy a solution to inconsistencies impinging on the hygiene hypothesis?. Clin Exp Allergy 2000; 30: 1506-1510.
• 20 Von Hertzen LC. Puzzling associations between childhood infections and the later occurrence of asthma and atopy. Ann Med 2000; 32: 397-400.
• 21 Holt PG. Parasites, atopy, and the hygiene hypothesis: resolution of a paradox?. Lancet 2000; 356: 1699-1701.
• 22 Kay AB. Advances in immunology: allergy and allergic diseases. N Engl J Med 2001; 344: 30-37.
• 23 Husby S. Sensitization and tolerance. Curr Opin Allergy Clin Immunol 2001; 1: 237-241.
• 24 Yazdanbakhsh M, van den Biggelaar A, Maizels RM. Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 2001; 22: 354-355.
• 25 Johnston SL. The protective effect of childhood infections: the next challenge is to mimic safely this protection against allergy and asthma. BMJ 2001; 322: 376-377.
• 26 Woodruff PG, Fahy JV. Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA 2001; 286: 395-398.
• 27 Matricardi PM. Prevalence of atopy and asthma in eastern versus western Europe: why the difference?. Ann Allergy Asthma Immunol 2001; 87 (Suppl. 03) 24-27.
• 28 Matricardi PM, Ronchetti R. Are infections protecting from atopy?. Curr Opin Allergy Clin Immunol 2001; 1: 413-419.
• 29 Martinez FD. The coming of age of the hygiene hypothesis. Respir Res 2001; 2: 129-132.
• 30 Von Mutius E, Braun-Fahrlander C, Schierl R. et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000; 30: 1230-1234.
• 31 Golding J. Immunizations. In: Butler N, Golding J. (eds). From Birth to Five. A Study of the Health and Behaviour of Britain's Five-Year-Olds. 1986. Oxford: Pergamon; 295-319.
• 32 Alm JS, Lilja G, Pershagen G, Scheynius A. Early BCG vaccination and development of atopy. Lancet 1997; 350: 400-403.
• 33 Hopkin JM. Early life receipt of antibiotics and atopic disorder. Clin Exp Allergy 1999; 29: 733-734.
• 34 Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-173.
• 35 Del Prete G. Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy 1992; 47: 450-455.
• 36 Maggi E, Parronchi P, Manetti R. et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992; 148: 2142-2147.
• 37 Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12: 227-257.
• 38 Martinez FD, Stern DA, Wright AL, Holberg CJ, Taussig LM, Halonen M. Association of interleukin-2 and interferon-gamma production by blood mononuclear cells in infancy with parenteral allergy skin tests and with susequent development of atopy. J Allergy Clin Immunol 1995; 96: 652-660.
• 39 Murphy E, Shibuya K, Hosken N. et al. A reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med 1996; 183: 901-913.
• 40 Yabuhara A, Macaubas C, Prescott SL, Venaille TJ, Holt BJ, Habre W. et al. Th2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy 1996; 27: 1261-1269.
• 41 Lambrecht BN. The dendritic cell in allergic airway diseases: a new player to the game. Clin Exp Allergy 2001; 31: 206-218.
• 42 Romagnani S. T-cell responses in allergy and asthma. Curr Opin Allergy Clin Immunol 2001; 1: 73-78.
• 43 Oro AS, Guarino TJ, Driver R, Steinman L, Umetsu DT. Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis. J Allergy Clin Immunol 1996; 97: 1402-1408.
• 44 Tang L, Benjaponpitak S, DeKruyff RH, Umetsu DT. Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production. J Allergy Clin Immunol 1998; 102: 428-435.
• 45 Verhoef CM, van Roon JA, Vianen ME, Bruijnzeel-Koomen CA, Lafcber FP, Biulsma JW. Mutual antagonism of rheumatoid arthritis and hay fever; a role for type 1 / type 2 T cell balance. Ann Rheum Dis 1998; 57: 275-280.
• 46 Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000; 105: 399-408.
• 47 Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000; 85: 9-21.
• 48 Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995; 182: 1527-1536.
• 49 Umetsu DT, Gieni R, DeKruyff RH. Effects of IL-12 in memory CD4+ T lymphocyte responses. Ann N Y Acad Sci 1996; 795: 88-99.
• 50 Hofstra C, Van Ark I, Hofman G, Kool M, Nijkamp FP, Van Oosterhout AJ. Prevention of the Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels. J Immunol 1998; 161: 5054-5060.
• 51 Kalyoncu AF, Stalenheim G. Serum IgE levels and allergic spectra in immigrants to Sweden. Allergy 1992; 47: 277-280.
• 52 Serafini U. Do infections protect against asthma and atopy?. Allergy 1997; 52: 955-957.
• 53 Campbell D, DeKruyff RH, Umetsu DT. Allergen immunotherapy: novel approaches in the management of allergic diseases and asthma. Clin Immunol 2000; 97: 193-200.
• 54 Horner AA, Van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Revi 2001; 179: 102-118.
• 55 Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax 1998; 53: 927-932.
• 56 Illi S, von Mutius E, Lau S. et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322: 390-395.
• 57 Droste JH, Wieringa MH, Weyler JJ, Nelen VJ, Vermeire PA, Van Bever HP. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?. Clin Exp Allergy 2000; 30: 1547-1553.
• 58 Matricardi PM, Rosmini F, Riondino S. et al. Exposure to foodbourne and orofecal microbies versus airbourne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000; 320: 412-417.
• 59 Brooks GD, Lemanske RF. Relation between house dust endotoxin exposure, type 1 T-cell development, and allergen sensitization in infants at high risk of asthma. Pediatrics 2001; 108: 544-545.
• 60 Kalliomaki M. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001; 357: 1076-1079.
• 61 Vanderhoof J. Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial. J Pediatrics 2001; 139: 750.
• 62 Isolauri E. Probiotics in the prevention and treatment of allergic disease. Pediatr Allergy Immunol Suppl 2001; 12 (Suppl. 14) 56-59.
• 63 McKinney PA, Okasha M, Parslow RC. et al. Early social mixing and childhood Type 1 diabetes mellitus: a case-control study. Diabet Med 2000; 17: 236-242.
• 64 Gibbon C, Smith T, Egger P, Betts P, Phillips D. Early infection and subsequent insulin dependent diabetes. Arch Dis Child 1997; 77: 384-385.
• 65 Rouse BT. Immunity to herpes simplex virus: a hypothesis. Herpes 2001; 8 (Suppl. 01) 2A-5A.
• 66 Morris J, Barker DJ, Nelson M. Diet, infection and acute appendicits in Britain and Ireland. J Epidem Commun Health 1987; 41: 44-49.
• 67 Walker AR, Segal I. What causes appendicitis?. J Clin Gastroenterol 1990; 12: 127-129.
• 68 Smith MA, Simon R, Strickler HD, McQuillan G, Ries LA, Linet MS. Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions. Cancer Causes Control 1998; 9: 237-239.
• 69 Teixeira MZ. Protocolo de pesquisa clı́nica em homeopatia: aspectos fundamentais. Diagnóstico Tratamento 2001; 6: 11-18.
• 70 Reilly DT, Taylor MA. Potent placebo or potency? A proposed study model with initial findings using homoeopathically prepared pollens in hay fever. BMJ 1985; 74: 65-75.
• 71 Reilly DT, Taylor MA, Mcsharry C, Aitchison T. Is homeopathy a placebo response? Controlled trial of homeopathy potency with pollen in hay fever as model. Lancet 1986; ii: 881-885.
• 72 Reilly DT, Taylor MA, Beattie NGM. et al. Is evidence for homeopathy reproducible?. Lancet 1994; 344: 1601-1606.
• 73 Reilly DT, Taylor MA, McSharry C. et al. Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. BMJ 2000; 321: 471-476.
• 74 Fisher P. Enough nonsense on immunization (editorial). Br Hom J 1990; 79: 198-200.
• 75 English JM. The rights and wrongs of measles vaccination. Br Hom J 1995; 84: 156-163.