Comparative effect of Coffea cruda potencies on rats

Abstract

The effects of Coffea cruda 30 and 200c and caffeine on the sleep pattern of rats were investigated. Treatments were administered orally at the beginning of the sleeping period. EEG from the parietal region was recorded. Delta (0.5–2.5 Hz) and slow (<1 Hz) waves are two of the major oscillation types that characterize neocortical electrical activity. The spectral power in these bands and the power ratio between 0.32–0.48 Hz and the delta band (slow/delta power ratio) for control and treatment groups were analyzed blind. Power in the delta band was significantly higher than baseline for Coffea 30c and caffeine (15.5 mg/kg). An increase in the slow/delta power ratio between control and treatment was detected for Coffea cruda 30 and 200c. Coffea 30c and caffeine have similar effects on sleep pattern, enhancing delta power; Coffea cruda 200c appears to affect only the synchronization.

Keywords

Coffea cruda - slow rhythm - delta rhythm - sleep - EEG - neocortex - rats

• References

• 1 Niedermeyer E, Lopes Da Silva F. Electroencephalography. Baltimore: Williams & Wilkins; 1981.
• 2 Contreras D, Steriade M. Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships. J Neurosc 1995; 15: 604-622.
• 3 Borbely AA. From slow waves to sleep homeostasis: new perspectives. Arch Ital Biol 2001; 139: 53-61.
• 4 Marks GA, Roffwarg HP. Spontaneous activity in the thalamic reticular nucleus during the sleep/wake cycle of the freely-moving rat. Brain Res 1993; 623: 241-248.
• 5 Schwierin B, Borbély AA, Tobler I. Effects of N⁶-cyclopentyladenosine and caffeine on sleep regulation in the rat. Eur J Pharmacol 1996; 300: 163-171.
• 6 Steriade M, Nuñez A, Amzica F. Intracellular analysis of relations between the slow (<1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram. J Neurosc 1993; 13: 3266-3283.
• 7 Ruiz-Vega G, Pérez-Ordaz L, Proa-Flores P, Aguilar-Dıaz Y. An evaluation of Coffea cruda on rats. Br Hom J 2000; 89: 122-126.
• 8 Ruiz G, Torres J-L. A possible characterization of the homeopathic effect. Br Hom J 1997; 86: 4-9.
• 9 Ruiz G, Torres J-L. Homeopathic effect on the sleep pattern of rats. Br Hom J 1997; 86: 201-206.
• 10 Ruiz G, Torres J-L, Michel O, Navarro R. Homeopathic effect on heart rate variability. Br Hom J 1999; 88: 106-111.
• 11 Vijnovksky V. Tratado de Materia Médica Homeopática. Buenos Aires: Macagno; 1978.
• 12 Barr M, Kiernan J. The Human Nervous System. Philadelphia: J.B. Lippincott Company; 1993.
• 13 Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. London: Academic Press; 1986.
• 14 Rechtschaffen A, Kales A. (eds). A Manual of Standardized Terminology, Techniques and Score System for Sleep Stages of Human Subjects. Bethesda: Education and WelfareUS Department of Health; 1968.
• 15 Borbély AA, Tobler I, Hanagasioglu M. Effect of sleep deprivation on sleep and EEG spectra in the rat. Behav Brain Res 1984: 171-182.
• 16 Statistica. Tulsa, OK, USA StatSoft, 1995.
• 17 Crow EL, Davis FA, Maxfield MW. Statistics Manual. New York: Dover Publication Corporation; 1960.
• 18 Zolman JF. Biostatistics. New York: Oxford University Press; 1993.
• 19 Borbély AA, Tobler I, Hanagasioglu M. Effect of sleep deprivation on sleep and EEG spectra in the rat. Behav Brain Res 1984: 171-182.
• 20 Landolt HP, Werth E, Borbely AA, Dijk DJ. Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night. Brain Res 1995; 675: 67-74.
• 21 Holtzman SG, Finn IB. Tolerance to behavioral effects of caffeine in rats. Pharmacol Biochem Behav 1988; 29: 411-418.
• 22 Holtzman SG, Finn IB. Tolerance to caffeine-induced stimulation of locomotor activity in rats. J Pharmacol Exp Ther 1986; 238: 542-546.
• 23 Vannier L. La Práctica de la Homeopatı́a México. Editorial Porrúa; 1956.
• 24 Kent JT. Filosofı́a Homeopática. Paharganj: B. Jain Publishers Pvt Ltd; 1993.
• 25 Hahnemann S. Organon of Medicine. Blaine: Cooper Publishing English; 1996.