CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2020; 55(01): 008-016
DOI: 10.1016/j.rboe.2018.03.001
Artigo de Revisão
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Association of ESRα XbaI A > G, ESRα PvuII T > C and ESRβ AlwNI T > C Polymorphisms with the Risk of Developing Adolescent Idiopathic Scoliosis: A Systematic Review and Genetic Meta-analysis[*]

Article in several languages: português | English
Mohammad Reza Sobhan
1  Departamento de Ortopedia, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Masoud Mahdinezhad-Yazdi*
1  Departamento de Ortopedia, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
2  Departamento de Genética Médica, Faculdade de Medicina, Shiraz University of Medical Sciences, Shiraz, Iran
,
Mohammadali Jafari
3  Departamento de Medicina de Emergência, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Ali Raee-Ezzabadi
3  Departamento de Medicina de Emergência, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Hossein Neamatzadeh
4  Departamento de Genética Médica, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5  Centro de Pesquisa em Saúde Materno-Infantil, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
› Author Affiliations
Further Information

Publication History

30 January 2018

13 March 2018

Publication Date:
09 January 2020 (online)

Abstract

Several association studies of genes polymorphisms on estrogen receptors-α and β with respect to adolescent idiopathic scoliosis (AIS) have been published in the past two decades. However, the association with AIS, especially among different ethnic subgroups, still remains controversial. Thus, we investigated these inconclusive data by performing a meta-analysis to systematically evaluate the association.

A literature search was conducted in the PubMed, ISI Web of Science, EMBASE, SCOPUS, EBSCO, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang databases until January 20, 2018. The strength of relationship was assessed using odds ratios (ORs) and 95% confidence intervals (95%CIs).

A total of 12 case–control studies with 4,304 cases of AIS and 3,123 controls met our criteria. The pooled ORs indicated that the ESRα XbaI A > G, ESRα PvuII T > C and ESRβ AlwNI T > C polymorphisms were not significantly associated with the risk of developing AIS in the overall analysis. However, we found a significant association between the ESRα XbaI A > G polymorphism and AIS under the homozygote model (GG versus AA; OR = 1.448, 95%CI: 1.052–1.993; p = 0.023).

The present meta-analysis suggests that the ESRα XbaI A > G, ESRα PvuII T > C and ESRβ AlwNI T > C polymorphisms may not be associated with the risk of developing AIS in the overall analysis. However, ESRα XbaI A > G might have an influence on the susceptibility to develop AIS among Asians. Considering the limited sample size and ethnicity, further larger studies are needed to provide a more precise estimation of the associations.

* Originally Published by Elsevier Editora Ltda.