CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2020; 55(05): 551-556
DOI: 10.1016/j.rbo.2018.01.001
Artigo Original

Comparative Effect between Infiltration of Platelet-rich Plasma and the Use of Corticosteroids in the Treatment of Knee Osteoarthritis: A Prospective and Randomized Clinical Trial[*]

Article in several languages: português | English
1   Faculty of Medicine, Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil
Philippe Mota Coutinho da Silva
1   Faculty of Medicine, Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil
Arthur Rangel Azevedo
2   Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo (Iamspe), São Paulo, SP, Brazil
Denison Santos Silva
3   Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil
Ronald Bispo Barreto da Silva
3   Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil
Juliana Cordeiro Cardoso
3   Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil
› Author Affiliations


Objectives This study aimed to analyze the efficacy of platelet-rich plasma obtained from the peripheral, autologous blood of the patients in pain complaints reduction and functional improvement of knee osteoarthritis compared with the standard treatment with injectable corticosteroid, such as triamcinolone.

Methods The patients were followed-up clinically at the preinfiltrative visit, with quantitative evaluation using the Knee Society Score (KSS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and the Kellgren and Lawrence scales. In addition, they were reevaluated with the same scales after 1 month and 6 months of intervention with 2.5 mL of triamcinolone acetate or 5 mL of platelet-rich plasma. The study was performed on 50 patients with knee osteoarthritis treated at the Medical Specialty Center and randomly divided into equivalent samples for each therapy.

Results The present study verified the reduction of pain scores, such as the WOMAC score, and elevations of functional scales, such as the KSS, evidenced in 180 days when using platelet-rich plasma, a therapy that uses the autologous blood of the patient and has fewer side effects.

Conclusion Although both platelet-rich plasma and corticosteroid therapies have been shown to be effective in the reduction pain complaints and functional recovery, there was a statistically significant difference between them at 180 days. According to the results obtained, platelet-rich plasma presented longer-lasting effects within 180 days in the treatment of knee osteoarthritis.

* Work performed at the Medical Specialty Center from Universidade Tiradentes (Unitmed), Aracaju, SE, Brazil Originally Published by Elsevier Editora Ltda.

Publication History

Received: 20 October 2017

Accepted: 04 January 2018

Publication Date:
03 February 2020 (online)

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