CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2019; 54(05): 556-563
DOI: 10.1016/j.rbo.2017.12.011
Artigo Original | Original Article
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revnter Publicações Ltda Rio de Janeiro, Brazil

Effectiveness of Prophylactic Intraosseous Antibiotic versus Intravenous Antibiotic in Knee Surgeries in Pigs: Experimental Study[*]

Article in several languages: português | English
Carlos Augusto de Mattos
1  Serviço de Ortopedia e Traumatologia, Hospital e Maternidade Celso Pierro, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil
,
1  Serviço de Ortopedia e Traumatologia, Hospital e Maternidade Celso Pierro, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil
,
Mariana de Oliveira Cyrino
1  Serviço de Ortopedia e Traumatologia, Hospital e Maternidade Celso Pierro, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil
,
Laura Credidio
2  Universidade Estadual de Campinas, Campinas, SP, Brasil
,
Natália Silveira Virgilli
3  Faculdade de Ciências Médicas, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil
,
Joaquim Simões Neto
4  Serviço de Cirurgia de Urgência de Trauma, Hospital e Maternidade Celso Pierro, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brasil
› Author Affiliations
Further Information

Publication History

29 August 2017

22 December 2017

Publication Date:
29 October 2019 (online)

Abstract

Objective To demonstrate that the intraosseous (IO) access is more effective compared with the intravenous (IV) access for prophylactic antibiotic administration in knee joint surgeries, using 36 pigs as live models.

Materials and Methods Skin, subcutaneous tissue, cartilage, and bone samples were collected, analyzed and compared after the administration of IV or IO antibiotic in different groups.

Results When comparing the IO and IV groups, the IO group showed a higher concentration of prophylactic antibiotic in the skin (p = 0.049), cartilage (p = 0.018), and bone (p = 0.002), in the analysis of the first 24 hours after 30 minutes of infusion.

Conclusion Since complications regarding this practice are rare, the use of this pathway may be an alternative to reduce the risk of surgical site infection in orthopedic surgeries, leading to a decrease in morbidity and mortality and hospital expenses with readmission or prolonged hospitalization time. However, further research and further experimental studies in humans are required, as the effectiveness of the method in pigs has been proved.

* Study developed at Hospital da Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil. Originally Published by Elsevier Editora Ltda.