CC BY-NC-ND 4.0 · Journal of Coloproctology 2015; 35(04): 230-237
DOI: 10.1016/j.jcol.2015.08.006
Review Article

Management of ulcerative colitis: a clinical update

Tratamento da retocolite ulcerativa: atualização clínica
Fabio Vieira Teixeira
a  Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil
b  Clínica Gastrosaúde de Marília, Marília, SP, Brazil
,
Rogerio Saad Hosne
c  Department of Surgery and Orthopedics, Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil
,
Carlos Walter Sobrado
d  Discipline of Coloproctology, Hospital das Clínicas, Universidade de São Paulo (USP), São Paulo, SP, Brazil
› Author Affiliations

Abstract

The objective of this study was to evaluate the consensus of expert societies and published guidelines on the management of ulcerative colitis, and to compare with the experience of the authors, in order to standardize procedures that would help the reasoning and decision-making process of the physician. A search was performed in scientific literature, specifically in electronic databases: Medline/Pubmed, SciELO, EMBASE and Cochrane, and the following descriptors were used: ulcerative colitis, acute colitis, clinical treatment, surgery and randomized trial. It can be concluded that the goals of therapy in ulcerative colitis are clinical and endoscopic remission, deep, sustained remission without corticosteroids, prevention of hospitalizations and surgeries, and improved quality of life. The surgical indications are reserved for selected cases, ranging from medical intractability, complications (severe refractory acute colitis, toxic megacolon, perforation and hemorrhage) and malignancy. Information in this review article must be submitted to evaluation and criticism of the specialist responsible for the conduct to be followed, in the face of his/her reality and the clinical status of each patient.

The degree of recommendation and strength of evidence were based using the GRADE system (The Grades of Recommendation, Assessment, Development, and Evaluation) described below:

1. A: Experimental or observational studies of higher consistency.

2. B: Experimental or observational studies of lower consistency.

3. C: Case reports (non-controlled studies).

4. D: Opinion without critical evaluation, based on consensus, physiological studies or animal models.

Resumo

O objetivo deste trabalho foi avaliar os consensos de sociedades de especialistas e guidelines publicados sobre o manejo da retocolite ulcerativa, e confrontar com a experiência dos autores, a fim de padronizar condutas que auxiliem o raciocínio e a tomada de decisão do médico. Foi realizada busca na literatura científica, mais precisamente nas bases de dados eletrônicos: Medline/Pubmed, SciELO, EMBASE e Cochrane, tendo sido utilizado os descritores: ulcerative colitis, acute colitis, clinical treatment, surgery e randomized trial. Pode-se concluir que os objetivos da terapia na retocolite ulcerativa são: remissão clínica e endoscópica, a remissão profunda sustentada sem corticosteróides, evitar hospitalizações e cirurgias, e melhora na qualidade de vida. As indicações cirúrgicas ficam reservadas para casos selecionados que variam de intratabilidade clínica, complicações (Colite aguda grave refratária, megacólon tóxico, perfuração e hemorragia) e malignização. As informações contidas neste artigo de revisão devem ser submetidas à avaliação e à crítica do médico especialista, responsável pela conduta a ser seguida, frente à sua realidade e ao estado clínico de cada paciente.

O grau de recomendaçã̃o e forç̧a de evidência foram baseados usando o GRADE system (The Grades of Recomendation, Assessment, Development, and Evaluation), descrito abaixo:

A: Estudos experimentais ou observacionais de melhor consistência.

B: Estudos experimentais ou observacionais de menor consistência.

C: Relatos de casos (estudos não controlados).

D: Opinião desprovida de avaliação crítica, baseada em consensos, estudos fisiológicos ou modelos animais.



Publication History

Received: 08 July 2015

Accepted: 15 August 2015

Publication Date:
17 February 2021 (online)

© 2015. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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