International Journal of Epilepsy 2016; 03(01): 42-62
DOI: 10.1016/j.ijep.2015.12.052
Abstracts
Thieme Medical and Scientific Publishers Private Ltd. 2017

Simple yet reliable pre-surgical evaluation for TLE in countries with limited resources, based on experience on 450 TLE cases

Zainal Muttaqin
,
M T Arifin
,
E Andar
,
Y Bakhtiar

Subject Editor:
Further Information

Publication History

Publication Date:
12 May 2018 (online)

Background: Despite the availability of modern antiepileptic drugs (AEDs), up to 30–40% of epilepsy patients continue to have seizures and half of these are potential candidates for surgery. Epilepsy surgery (ES) is recommended for temporal lobe epilepsy (TLE), which is possibly the most common form of human epilepsy and the most refractory to AEDs. In TLE, the surgical procedure is a standardized anterior temporal lobectomy (ATL) including amygdalo-hippocampectomy, or selective amygdalo-hippocampectomy (SAH). So that all pre-surgical evaluation is aimed to finding the epileptic temporal side.

Methods: Based on our experience on surgery of 450 TLE cases, pre-surgical evaluations are grouped into 1 – simple (based only on semiology and the presence of uni-lateral temporal or hippocampal abnormality), 2 – difficult (long-term ictal EEG and/or FDG-PET evaluation is needed), and 3 – complex (invasive subdural EEG is needed). These groups of pre-surgical work-up are evaluated in relation to the results of surgery, evaluated after at least 12 months follow-up.

Results: There were more than 50% patients in Group 1 (simple work-up), and the result showed that even based on seizure semiology and MRI only, seizure free (SF) rate reached more than 70% cases and comparable with those TLE cases needed more difficult or even complex pre-surgical work-up.

Conclusion: There are many countries with limited resources with so many intractable TLE cases which may go directly into ES after simple yet reliable pre-surgical evaluation. Understanding the limitation and good patient selection criteria are important so that Epilepsy Surgery may be started in many areas with limited resources.