Use of multi-modal imaging to improve the localization of epileptogenic focus

Multi-modal imaging using MRI, PET, SPECT along with MEG provides the best possible option to localize the epileptogenic focus non-invasively. The option to use it with intra-operative MRI along with neuronavigation provides the best possible option to localize the epileptogenic focus. The paper describes the centre's experience in localizing the epileptogenic focus for extra temporal and lateral temporal pathologies by co-registering MRI, PET, SPECT and MEG. In addition, intra operative ECoG was use to localize the focus at surgery. The center has now experience with over 100 cases from an experience of over 1500 cases of epilepsy surgery where this technique was used. The preliminary experience is described here.