International Journal of Epilepsy 2015; 02(02): 090-093
DOI: 10.1016/j.ijep.2015.07.001
Case Report
Thieme Medical and Scientific Publishers Private Ltd.

Refractory status epilepticus: Febrile Illness Related Epileptic Syndrome (FIRES)

Varun Kumar Sharma
1  Jaslok Hospital and Research Centre, Mumbai, India
,
Anaita Udwadia Hegde
1  Jaslok Hospital and Research Centre, Mumbai, India
,
Fazal Nabi
1  Jaslok Hospital and Research Centre, Mumbai, India
› Author Affiliations

Subject Editor:
Further Information

Publication History

Received: 26 November 2014

Accepted: 20 July 2015

Publication Date:
06 May 2018 (online)

Abstract

In recent literature, a new entity has emerged, which focuses on a possible non-encephalitic epileptic encephalopathy precipitated by fever in a previously normal child. We report a typical case of Febrile illness related epileptic syndrome (FIRES) from Indian subcontinent. The index case presented with fever and multiple seizures, which progressed to status epilepticus and encephalopathy. All infectious, metabolic and autoimmune markers were negative. Convulsions were refractory to all possible treatment except thiopentone which achieved burst suppression pattern. Breakthrough seizures were prevented by using lacosamide and ketogenic diet along with multiple anticonvulsants. At 1-year follow-up, patient had a relatively good neurological outcome, however has persistent refractory epilepsy.