International Journal of Epilepsy 2015; 02(02): 084-086
DOI: 10.1016/j.ijep.2014.06.002
Case Report
Thieme Medical and Scientific Publishers Private Ltd.

Status epilepticus as presenting manifestation of H1N1 infection

Aastha Takkar
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Manoj Kumar Goyal
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Manish Modi
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Parampreet S. Kharbanda
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Lakshminarayana Yaddanapudi
b   Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Vivek Lal
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
,
Sudesh Prabhakar
a   Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India
› Institutsangaben

Verantwortlicher Herausgeber dieser Rubrik:
Weitere Informationen

Publikationsverlauf

Received: 05. November 2013

Accepted: 29. Juni 2014

Publikationsdatum:
06. Mai 2018 (online)

Abstract

Background During the global H1N1 pandemic, neurological complications were reported in approximately 6–10% of children suffering from H1N1 infection, but only rarely in adults. Generalized convulsive status epilepticus (GCSE) as a presenting manifestation of H1N1 infection in an adult is exceedingly rare and has not been reported in literature. We report a patient who presented to us with GCSE as a presenting manifestation of H1N1 infection who improved following appropriate antiviral treatment.

Methods and results This 20-year-old gentleman presented to us with history of fever followed by GCSE of 24 h duration. He was treated symptomatically and was evaluated in detail. He was diagnosed to be suffering from H1N1 infection based on appropriate serological tests. After start of antiviral therapy, he improved and is doing well at 4 months follow up.

Conclusion This case report further expands the spectrum of clinical findings associated with sporadic H1N1 infection. A possibility of H1N1 infection should be considered in all patients who present with GCSE without any obvious cause so that appropriate diagnostic tests and treatment can be carried out at the earliest.

 
  • References

  • 1 Novel Swine Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza virus (H1N1) in humans. N Engl J Med 360 2009; 2605-2615
  • 2 Ekstrand JJ, Herbener A, Rawlings J. et al. Heightened neurologic complications in children with pandemic H1N1 influenza. Ann Neurol 68 2010; 762-766
  • 3 Davis LE. Neurologic and muscular complications of the 2009 influenza A (H1N1) pandemic. Curr Neurol Neurosci Rep 10 2010; 476-483
  • 4 Khandaker G, Zurynski Y, Buttery J. et al. Neurologic complications of influenza A(H1N1): surveillance in 6 pediatric hospitals. Neurology 79 2012; 1474-1481
  • 5 To KK, Hung IF, Li IW. et al. Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection. Clin Infect Dis 50 2010; 850-859
  • 6 Kitcharoen S, Pattapongsin M, Sawanyawisuth K, Angela V, Tiamkao S. Neurological manifestations of pandemic (H1N1) 2009 virus infection. Emerg Infect Dis 16 2010; 569-570
  • 7 Yeo LL, Paliwal PR, Tambyah PA, Olszyna DP, Wilder-Smith E, Rathakrishnan R. Complex partial status epilepticus associated with adult H1N1 infection. J Clin Neurosci 19 2012; 1728-1730
  • 8 Morishima T, Togashi T, Yokota S. et al. Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 35 2002; 512-517
  • 9 Kaiser L, Wat C, Mills T, Mahoney P, Ward P, Hayden F. Impact of oseltamivir on influenza related lower respiratory tract complications and hospitalizations. Arch Intern Med 163 2003; 1667-1672