Establishing the interfacial nano-structure and elemental composition of homeopathic medicines based on inorganic salts: a scientific approach
Received18. August 2014
revised08. Mai 2015
accepted21. September 2015
28. Dezember 2017 (online)
Extremely dilute systems arise in homeopathy, which uses dilution factors 1060, 10400 and also higher. These amounts to potencies of 30c, 200c or more, those are far beyond Avogadro's number. There is extreme skepticism among scientists about the possibility of presence of starting materials due to these high dilutions. This has led modern scientists to believe homeopathy may be at its best a placebo effect. However, our recent studies on 30c and 200c metal based homeopathic medicines clearly revealed the presence of nanoparticles of starting metals, which were found to be retained due to the manufacturing processes involved, as published earlier.9,10 Here, we use HR-TEM and STEM techniques to study medicines arising from inorganic salts as starting materials. We show that the inorganic starting materials are present as nano-scale particles in the medicines even at 1 M potency (having a large dilution factor of 102000). Thus this study has extended our physicochemical studies of metal based medicines to inorganic based medicines, and also to higher dilution. Further, we show that the particles develop a coat of silica: these particles were seen embedded in a meso-microporous silicate layer through interfacial encapsulation. Similar silicate coatings were also seen in metal based medicines. Thus, metal and inorganic salt based homeopathic medicines retain the starting material as nanoparticles encapsulated within a silicate coating. On the basis of these studies, we propose a universal microstructural hypothesis that all types of homeopathic medicines consist of silicate coated nano-structures dispersed in the solvent.
- 1 Davenas E., Beauvais F., Amara J. et al. Human basoph degranulation triggered by very dilute antiserum against IgE. Nature 1988; 333: 816-818.
- 2 Chaplin M.F. The memory of water: an overview. Homeopathy 2007; 96: 143-150.
- 3 Teixeira J. Can water possibly have a memory? a sceptica view. Homeopathy 2007; 96: 158-162.
- 4 Rao M.L., Roy R., Bell I.R., Hoover R. The defining role of structure (including epitaxy) in the plausibility of homeopathy. Homeopathy 2007; 96: 175-182.
- 5 Anagnostatos G.S. Small water clusters (Clathrates) in the homoeopathic preparation process. In: Endler PC, Schulte J (eds). Ultra High Dilution − Physiology and Physics 1994. Kluwe Academic Publishers; Dordrecht, The Netherlands: 121-128.
- 6 Walach H., Jonas W.B., Ives J., van Wijk R., Weingärtner O. Research on homeopathy: state of the art. J Altern Complement Med 2005; 11: 813-829.
- 7 Davydov A.S. Energy and electron transport in biological systems. In: Ho MW, Popp FA, Warnke U (eds). Bioelectrodynamics and Biocommunication 1994. World Scientific Publishing Co. Pte. Ltd; Singapore: 411-430 [Chap. 17].
- 8 Anick D.J., Ives J.A. The silica hypothesis for homeopathy: physical chemistry. Homeopathy 2007; 96: 189-195.
- 9 Chikramane P.S., Suresh A.K., Bellare J.R., Kane S.G. Extreme homeopathic dilutions retain starting materials: a nanoparticulate perspective. Homeopathy 2010; 99: 231-242.
- 10 Chikramane P.S., Kalita D., Suresh A.K., Kane S.G., Bellare J.R. Why extreme dilutions reach non-zero asymptotes: a nanoparticulate hypothesis based on froth flotation. Langmuir 2012; 13 (28) 15864-15875.
- 11 Liz-Marzán L.M., Giersig M., Mulvaney P. Synthesis of nanosized gold-silica core-shell particles. Langmuir 1996; 12: 4329-4335.
- 12 Ung T., Liz-Marzán L.M., Mulvaney P. Controlled method for silica coating of silver colloids. influence of coating on the rate of chemical reactions. Langmuir 1998; 14: 3740-3748.
- 13 Marinakos S.M., Shultz D.A., Feldheim D.L. Gold nanoparticles as templates for the synthesis of hollow nanometer-sized conductive polymer capsules. Adv Mater 1999; 11: 34-37.
- 14 Hardikar V.V., Matijevic E. Coating of nanosize silver particles with silica. J Colloid Interface Sci 2000; 221: 133-136.
- 15 Hall S.R., Davis S.A., Mann S. Condensation of organosilica hybrid shells on nanoparticle templates: a direct synthetic route to functionalized core−shell colloids. Langmuir 2000; 16: 1454-1456.
- 16 Mulvaney P., Liz-Marzán L.M., Giersig M., Ung T. Silica encapsulation of quantum dots and metal clusters. J Mater Chem 2000; 10: 1259-1270.
- 17 Kobayashi Y., Correa-Duarte M.A., Liz-Marzán L.M. Sol−gel processing of silica-coated gold nanoparticles. Langmuir 2001; 17: 6375-6379.
- 18 Cho G., Fung B.M., Glatzhofer D.T., Lee J.S., Shul Y.G. Preparation and characterization of polypyrrole-coated nanosized novel ceramics. Langmuir 2001; 17: 456-460.
- 19 Tago T., Hatsuta T., Nagase R., Kishida M., Wakabayashi K. Kagaku Kogaku Ronbunshu 2001; 27: 288 [in Japanese].
- 20 Wang H., Nakamura H., Yao Y., Maeda H., Abe E. Effect of solvents on the preparation of silica-coated magnetic particles. 2001; Chem Lett 1168-1169.
- 21 Lu Y., Yin Z., Li Z., Xia Y. Synthesis and self-assembly of Au@SiO2 core-shell colloids. Nano Lett 2002; 2: 785-788.
- 22 Jana N.R., Earhart C., Ying J.Y. Synthesis of water-soluble and functionalized nanoparticles by silica coating. Chem Mater 2007; 19: 5074-5082.
- 23 Dimas D., Giannopaulou I., Panias D. Polymerization in sodium silicate solutions: a fundamental process in geopolymerization technology. J Mat Sc 2009; 44: 3719-3730.
- 24 Attard P. The stability of nanobubbles. Eur Phys J Sp Top 2013; 1-22.
- 25 Varma P.N., Vaid I. Encyclopedia of Homoeopathic Pharmacopoeia & Drug; Index B. 2007. Jain Publishers; New Delhi: 2722-2745.
- 26 Joo S.H., Park J.Y., Tsung C.K., Yamada Y., Yang P., Somorjai G.A. Thermally stable Pt/mesoporous silica core–shell nanocatalysts for high-temperature reactions. Nat Mater 2009; 8: 126-131.
- 27 Egerton R.F., Li P., Malac M. Radiation damage in the TEM and SEM. Micron 2004; 35: 399-409.
- 28 Kinradet S.D., Pole D.L. Effect of alkali-metal cations on the chemistry of aqueous silicate solutions. Inorg Chem 1992; 31: 4558-4563.
- 29 University of Maine, Lecture connections homepage, polymers: slime & superball http://interchemnet.um.maine.edu/newnav/Homepage/Highschool/Slime/lecpolymers2.htm [accessed January 3, 2014].
- 30 Gill I., Ballesteros A. Encapsulation of biologicals within silicate, siloxane, and hybrid sol-gel polymers: an efficient and generic approach. J Am Chem Soc 1998; 120: 8587-8598.
- 31 Ives J.A., Moffett J.R., Peethambaran A. et al. Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions. Homeopathy 2010; 99: 15-24.