Solvatochromic dyes detect the presence of homeopathic potencies
Received12 March 2015
revised18 June 2015
accepted12 August 2015
23 December 2017 (online)
A systematic approach to the design of simple, chemical systems for investigating the nature of homeopathic medicines has led to the development of an experimental protocol in which solvatochromic dyes are used as molecular probes of serially diluted and agitated solutions. Electronic spectroscopy has been used to follow changes in the absorbance of this class of dyes across the visible spectrum in the presence of homeopathic potencies.
Evidence is presented using six different solvatochromic dyes in three different solvent systems. In all cases homeopathic potencies produce consistent and reproducible changes in the spectra of the dyes.
Results suggest that potencies influence the supramolecular chemistry of solvatochromic dyes, enhancing either dye aggregation or disaggregation, depending upon dye structure. Comparable dyes lacking the intramolecular charge transfer feature of solvatochromic dyes are unaffected by homeopathic potencies, suggesting potencies require the oscillating dipole of solvatochromic dyes for effective interaction.
The implications of the results presented, both for an eventual understanding of the nature of homeopathic medicines and their mode of action, together with future directions for research in this area, are discussed.
- 1 Reichardt C., Welton T. Solvent effects on the absorption spectra of organic compounds. Solvents and Solvent Effects in Organic Chemistry. 4th edn Weinheim.Wiley-VCH: 2011: 359-424.
- 2 Wolf U., Wolf M., Heusser P., Thurneysen A., Baumgartner S. Homeopathic preparations of quartz, sulphur and copper sulphate assessed by UV-spectroscopy. Evid Based Complement Altern Med 2011; 644-654.
- 3 Aabel S., Fossheim S., Rise F. Nuclear magnetic resonance (NMR) studies of homeopathic solutions. Br Homeopath J 2001; 90: 14-20.
- 4 Rey L. Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride. Phys A Stat Mech Appl 2003; 323: 67-74.
- 5 Assumpcao R. Electrical impedance and HV plasma images of high dilutions of sodium chloride. Homeopathy 2008; 97: 129-133.
- 6 Elia V., Baiano S., Duro I., Napoli E., Niccoli M., Nonatelli L. Permanent physico-chemical properties of extremely diluted aqueous solutions of homeopathic medicines. Homeopathy 2004; 93: 144-150.
- 7 Belon P., Elia V., Elia L., Montanino M., Napoli E., Niccoli M. Conductometric and calorimetric studies of the serially diluted and agitated solutions. On the combined anomalous effect of time and volume parameters. J Therm Anal Calorim 2008; 93 (02) 459-469.
- 8 Bell I.R. The evolution of homeopathic theory-driven research and methodological toolbox. Am Homeopath 2008; 14: 56.
- 9 Montagnier L., Aissa J., Ferris S., Montagnier J.-L., Lavallee C. Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences. Interdiscip Sci Comput Life Sci 2009; 1: 81-90.
- 10 Yin Lo S., Geng X., Gann D. Evidence for the existence of stable-water-clusters at room temperature and normal pressure. Phys Letts A 2009; 373 (42) 3872-3876.
- 11 Marchettini N., Del Giudice E., Voeikov V., Tiezzi E. Water: a medium where dissipative structures are produced by a coherent dynamics. J Theor Biol 2010; 265: 511-516.
- 12 Milgrom L.R. Entanglement, knowledge, and their possible effects on the outcomes of blinded trials of homeopathic provings. J Altern Complement Med 2006; 12 (03) 271-279.
- 13 Bellavite P. Complexity science and homeopathy: a synthetic overview. Homeopathy 2003; 92 (04) 203-212.
- 14 Torres J.L., Ruiz M.A.G. Stochastic resonance and the homeopathic effect. Br Homoeopath J 1996; 85: 134-140.
- 15 Speight P. Homoeopathy: a home prescriber. C W Daniel Co Ltd; UK: 1992.
- 16 Hahnemann S. Organon of medicine. 5th and 6th edns.
- 17 Reichardt C. Pyridinium N-phenolate betaine dyes as empirical indicators of solvent polarity: some new findings. Pure Appl Chem 2008; 80 (07) 1415-1432.
- 18 Reichardt C. Solvatochromic dyes as solvent polarity indicators. Chem Rev 1994; 94: 2319-2358.
- 19 Banfield P., Hutchings M.G. Chromic phenomena: technological applications of colour chemistry. 2nd edn RSC Publishing; Cambridge, UK: 2010.
- 20 Wurthner F., Yao S., Debaerdemaeker T., Wortmann R. Dimerization of merocyanine dyes. Structural and energetic characterization of dipolar dye aggregates and implications for nonlinear optical materials. J Am Chem Soc 2002; 124: 9431-9447.
- 21 Cartwright SJ. Unpublished results 2015.
- 22 Eisfeld A., Briggs J.S. The J- and H- bands of organic dye aggregates. Chem Phys 2006; 324: 376-384.
- 23 Mishra A., Behera R.K., Behera P.K., Mishra B.M., Behera G.B. Cyanines during the 1990's. Chem Rev 2000; 100 (06) 1973-2012.
- 24 Balzani V., Ceroni P., Juris A. Photochemistry and photophysics: concepts, research, applications. Wiley-VCH Weinheim; Germany: 2014.
- 25 Reichardt C. Solvatochromism, thermochromism, piezochromism, halochromism and chiro-solvatochromism of pyridinium N-phenoxide betaine dyes. Chem Soc Rev 1992; 21: 147-153.
- 26 Chaplin M. The memory of water: an overview. Homeopathy 2007; 96: 143-150.
- 27 Davenas E., Beauvais F., Amara J. et al. Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 1988; 333 6176 816-818.
- 28 http://www.helios.co.uk/remedies/remedy-preparation.