Homeopathy 2014; 103(01): 74
DOI: 10.1016/j.homp.2013.10.028
Abstracts - Oral Presentation
Copyright © The Faculty of Homeopathy 2013

Model validity of randomised placebo-controlled trials of individualised homeopathic treatment

Robert T. Mathie
Michel Van Wassenhoven
Rajkumar K. Manchanda
Laurence Terzan
Gilles Chaufferin
Flávio Dantas
Jennifer Jacobs
Joyce Frye
Menachem Oberbaum
John A. Ives
Helmut Roniger
Peter Fisher

Subject Editor:
Further Information

Publication History

Publication Date:
24 January 2018 (online)

Purpose : A new programme of systematic reviews of randomised controlled trials (RCTs) of homeopathy distinguishes several key attributes of study design and quality: placebo controlled cf. other-than-placebo controlled; individualised cf. non-individualised homeopathy; treatment cf. prophylaxis; internal validity cf. model validity. The present phase of the review programme focuses on assessing the model validity (MV) of peer-reviewed, placebo-controlled, RCTs of individualised homeopathic treatment.

Methods : A systematic literature search and subsequent reappraisal of retrieved records identified 31 RCTs that satisfied the inclusion criteria for the present study. MV of the eligible RCTs was appraised using a novel criterion-based method. Assessment domains address: (i) the rationale for the choice of the particular homeopathic intervention; (ii) the homeopathic principles reflected in the intervention; (iii) the extent of homeopathic practitioner input; (iv) the relevance of the main outcome measure; (v) the capability of the main outcome measure to detect change; (vi) the length of follow-up to the endpoint of the study. These six MV domains per RCT were categorised by each of three independent assessors as ‘acceptable’, ‘unclear’ or ‘unacceptable’, disparities of opinion being resolved by consensus discussion.

Results : Domain-specific and overall ratings of MV per RCT await the outcome of ongoing consensus discussions. A full set of findings will be presented at conference.

Conclusions : MV data contribute importantly to the appraisal of RCT quality in systematic reviews of homeopathy.