The therapeutic effect of Tarentula cubensis extract (Theranekron ®) in foot-and-mouth disease in cattle: a randomised trial in an endemic setting
Received16 July 2011
revised17 May 2012
accepted24 May 2012
29 December 2017 (online)
Background: Foot-and-mouth disease (FMD) is a contagious viral disease of ruminant animals. Eradication of disease in western countries is by slaughter of infected and in contact animals but this is not possible in endemic countries. There is no standard treatment for FMD in endemic countries, but anti-inflammatory drugs and mild disinfectant and protective dressing to inflamed areas to prevent secondary infection is recommended.
Method: A randomised controlled clinical trial of a homeopathic preparation of Tarentula cubensis (Theranekron ®) was conducted during an outbreak of FMD in cattle in Iran. A single subcutaneous injection of Theranekron ® was used as sole treatment in 50 infected animals (treatment group). The control group comprised 15 infected animals treated with standard medication including: daily injection of flunixin meglumine and oxytetracycline and daily dressing of lesions with 4% sodium carbonate. Systemic and local signs were recorded over 14 days.
Results: Rectal temperature in treatment group subsided to normal range within 1 day of homeopathic treatment, and was significantly lower in test group than in control group on several successive days (P < 0.05). Healing of inflamed mucosal areas and appetite score of the treatment was significantly better than control during first 3 days of treatment (P < 0.05).
Conclusion: It appears that Theranekron ® is effective for treatment of systemic and local signs of FMD-infected cattle. Further research is justified.
- 1 OIE. Manual of diagnostic tests and vaccines for terrestrial animals. Chapter 2.1.5. Available at: 6th edn. 2009. http://www.oie.int/fr/normes/mmanual/A_summry.htm [accessed 20.1.2010].
- 2 Yang P.C., Chu R.M., Chung W.B. et al. Epidemiological characteristics and financial costs of the 1997 foot-and-mouth disease epidemic in Taiwan. Vet Rec 1999; 25: 731-734.
- 3 Salt J.S. The carrier state in foot and mouth disease – an immunological review. Br Vet J 1993; 149: 207-223.
- 4 Keller K., Greiner S., Stockebrand P. Homöopathische arzneimittel materialien zur bewertung, einschlieβlich 6. Berlin: Govi-Verlag; 1995.
- 5 Stampa S. A field trial comparing the efficacy of sulfamonomethoxine, penicillin, and tarantula poison in the treatment of pododermatitis circumspecta of cattle. J S Afr Vet Assoc 1986; 57: 91-93.
- 6 Koch H., Stein M. Conservative therapy of neoplastic changes of the lactiferous gland of dogs with theranekron. Der Praktische Tierarzt 1980; 5: 1-4.
- 7 Sardari K., Galedar Kakhki E., Mohri M. Evaluation of wound contraction and epithelialization after subcutaneous administration of Theranekron ® in cows. Comp Clin Pathol 2007; 16: 197-200.
- 8 Mezger J. Prospected homeopathic pharmaceutical product device. Australas Nurses 1977; 2: 1418-1421.
- 9 Hughes R., Dake J.P. A cyclopedia of drug pathogenesy. New Delhi: B. Jain Publisher, n. d; 1891.
- 10 Veiga S.S., Feitosa L., Dos Santos V.L.P. et al. Effect of brown spider venom on basement membrane structures. Histochem J 2000; 32: 397-408.
- 11 Tyler M.L. Homeopathic drug pictures. New Delhi: B Jain Publishers; 1992. pp. 798–809.
- 12 Richardson- Boedler C. The brown spider Loxosceles laeta: source of the remedy Tarantula cubensis?. Homeopathy 2002; 91: 166-170.
- 13 Della-Porta A.J. Current status of foot-and-mouth disease vaccines including the use of genetic engineering. Aust Vet J 1983; 60: 129.
- 14 Richardson-Boedler C. A potential antidote for the necrotic and systemic effects caused by the brown spider (Loxosceles recluse): a homeopathic preparation from the spider. J Am Inst Hom 1998; 91: 277-283.
- 15 Snowden J.M. Wound contraction. A quantitative interpretation. Aust J Exp Biol Med Sci 1981; 59: 203-217.
- 16 Harari J. Surgical complications and wound healing in the small animal practice. Philadelphia: WB Saunders Co; 1993. pp. 78–79.
- 17 Benitz AM, 1984. In: Proceedings of 13th World Congress on Diseases of Cattle, Durban, South Africa. Cited in: Radostitis OM, Gay CC, Hinchcliff KW, Constable PD (eds). Veterinary Medicine, 10th edn, Edinburgh: Saunders-Elsevier, 2007.
- 18 Gibson D. Studies of homeopathic remedies. Beaconsfield: Beaconsfield Publishers Ltd; 1987.
- 19 Clarke J.H. A dictionary of practical material medica. 3 vols (reprint) New Delhi: Homeopathic Publications, n. d; 2009. pp. 1900–1903.
- 20 Boericke W. Pocket of homeopathic material medica. The University of Michigan; 1903. pp. 606–610.