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Homeopathy 2009; 98(04): 280-286
DOI: 10.1016/j.homp.2009.09.002
 
Copyright © The Faculty of Homeopathy 2009

The rat in basic therapeutic research in homeopathy

R. van Wijk
1   Faculty of Biology, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
,
J. Clausen
2   Karl und Veronica Carstens-Stiftung, Am Deimelsberg 36, 45276 Essen, Germany
,
H. Albrecht
2   Karl und Veronica Carstens-Stiftung, Am Deimelsberg 36, 45276 Essen, Germany
› Author Affiliations
Subject Editor:
Further Information

Publication History

Received09 March 2009
revised25 June 2009

accepted07 September 2009

Publication Date:
15 December 2017 (online)

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The Similia Principle, the basis of homeopathy, implies that substances initiating symptoms when applied to healthy biological systems can be utilized as remedies to treat a diseased system with similar symptoms. Depending whether the remedy substance was of the same type as the etiologic agent, treatment is classified as either homologous or heterologous. The intact rat is the biological system most utilized in basic science homeopathic research. The Homeopathy Basic Research experiments (HomBRex) database (about 1300 experiments on model biological systems in homeopathic research) was analyzed for homologous and heterologous treatments of disease states of intact rats. The relationship between the Similia Principle and hormesis is discussed.

Keywords

Basic research - Database - Homeopathy - Rat - Similia principle - Hormesis
 

  • References

  • 1 Albrecht H., Van Wijk R., Dittloff S. A new database on basic research in homeopathy. Homeopathy 2002; 91 (03) 162-165.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Van Wijk R., Albrecht H. Classification of systems and methods used in biological basic research on homeopathy. Homeopathy 2007; 96 (04) 247-251.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Van Wijk R., Albrecht H. Proving and therapeutic experiments in the HomBRex basic homeopathy research database. Homeopathy 2007; 96 (04) 252-257.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Schroyens F. Repertorium homeopathicum syntheticum. 7th edn. Greifenberg: Hahnemann Institut für homöopathische Dokumentation; 1998. pp 1–1839
    Google Scholar
  • 5 Van Wijk R., Wiegant F.A.C. The Similia principle. An experimental approach on the cornerstone of homeopathy. Essen: KVC-Verlag; 2006. pp 1–113
    Google Scholar
  • 6 Southam C.M., Ehrlich J. Effects of extract of western red-ceder heartwood on certain wood-decaying fungi in culture. Phytopathol 1943; 33: 517-524.
    PubMedGoogle Scholar
  • 7 Neafsey P.J. Longevity hormesis. A review. Mech Ageing Dev 1990; 51 (01) 1-31.
    CrossrefPubMedGoogle Scholar
  • 8 Calabrese E.J., Baldwin L.A. Defining hormesis. Hum Exp Toxicol 2002; 21 (02) 91-97.
    CrossrefPubMedGoogle Scholar
  • 9 Stebbing A.R.D. A mechanism for hormesis – a problem in the wrong discipline. Crit Rev Toxicol 2003; 33 (03/04) 463-467.
    CrossrefPubMedGoogle Scholar
  • 10 Luckey T.D. Hormesis with ionizing radiation. Boca Raton: CRC Press Inc.; 1980. pp 1–222
    Google Scholar
  • 11 Calabrese E.J., Bachmann K.A., Bailer A.J. et al. Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework. Toxicol Appl Pharmacol 2007; 222 (01) 122-128.
    CrossrefPubMedGoogle Scholar
  • 12 Calabrese E.J. Hormesis and medicine. Br J Clin Pharmacol 2008; 66 (05) 594-617.
    PubMedGoogle Scholar
  • 13 Van Wijk R., Ooms H., Wiegant F.A.C. et al. A molecular basis for understanding the benefits from subharmful doses of toxicants. Environ Managem Health 1994; 5 (01) 13-25.
    PubMedGoogle Scholar
  • 14 Bastide M. Basic research on high dilution effects. In: Taddei-Ferretti C., Marotta P. High Dilution Effects on Cells and Integrated Systems. 1998. Singapore: World Scientific; 3-5
    CrossrefGoogle Scholar
  • 15 Bellavite P., Conforti A., Pontarollo F., Ortolani R. Immunology and homeopathy. 2. Cells of the immune system and inflammation. eCAM 2006; 3 (01) 13-24.
    PubMedGoogle Scholar
  • 16 Boiron J. A homeopathic study of homeopathic solutions and the retention and mobilization of arsenic in rats. J. LMHI 1987; 4 (01) 27-29.
    PubMedGoogle Scholar
  • 17 Boiron J., Belon P., Abecassis J., Cazin J.C., Gaborit J.L. Effets d'arsenicum album 7 CH chez des rats intoxiques par l'arsenic. In: LMHI Proceedings of the 35e Congres de la Ligue Médicale Homéopathique Internationale. 1982. Brighton: Liga Medicorum Homeopathica Internationalis (LMHI); 307-319
    Google Scholar
  • 18 Cazin J.C., Cazin M., Gaborit J.L. et al. A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilization of arsenic in the rat. Hum Toxicol 1987; 6 (04) 315-320.
    CrossrefPubMedGoogle Scholar
  • 19 Cazin J.C., Cherruault Y. Etude pharmacologique de dilutions Hahnemanniennes sur la retention et la mobilisation de l'arsenic chez le rat. In: Boiron J. Recherches en homéopathie. 1986. Lyon: Fondation Française pour la Recherche en Homéopathie; 19-39
    Google Scholar
  • 20 Gaborit JL. Contribution à la recherche de modèles biologiques chez la mammifères, permettant de visualiser l'action de différentes facteurs physiques sur l'activité des dilutions infinitésimales. Thesis, Université de Lille II, 1987.
    PubMed
  • 21 Gaborit JL. Etude pharmacologique de rétention et de la mobilisation de l'arsenic sous l'effet de doses infinitésimales d'arsenic. Thesis, Université de Lille II, 1981.
    PubMed
  • 22 Boiron J., Cier A., Vingert C. Effets de quelques facteurs physiques sur l'activité pharmacologiques de dilutions infinitésimales. Ann Homeopath Fr 1968; 10 (03) 187-196.
    PubMedGoogle Scholar
  • 23 Cazin J.C., Chaoui A., Belon P. Influence of several physical factors on the activity of ultra low doses. In: Doutremepuich C. Ultra Low Doses. 1991. London: Taylor & Francis; 69-80 (Chap 2)
    Google Scholar
  • 24 Boiron J., Cier A. Elimination provoquée et specificité d'action des dilutions infinitésimales d'éléments toxiques. Ann Homeopath Fr 1962; 4 (10) 789-795.
    PubMedGoogle Scholar
  • 25 Cier A., Boiron J., Vingert C. Essais Pharmacologiques de nouvelles dilutions korsakowiennes. Ann Homeopath Fr 1965; 7 (08) 597-600.
    PubMedGoogle Scholar
  • 26 Fisher P., Belon P., Turner P. The influence of the homoeopathic remedy plumbum metallicum on the excretion kinetics of lead in rats. Hum Toxicol 1987; 6 (04) 321-324.
    CrossrefPubMedGoogle Scholar
  • 27 Vischniac I. Influence des doses infinitésimales de plomb sur l'évolution de l'intoxication au plomb chez l'animal. Homeopath Fr 1965; 53 (01) 21-33.
    PubMedGoogle Scholar
  • 28 Guillemain J., Narcisse G., Ernouf D.C., Sepchat P. Subacute intoxication with lead in rats: influence of the homoeopathic remedy plumbum metallicum versus penicillinamine. In: Bastide M., Campbell A., Halm R.P., Narcisse G. Signals and Images. Abstracts—Book of the 3rd GIRI Symposium. 1989. Paris: Atelier Alpha Blue; 124-125
    Google Scholar
  • 29 Sukul N.C., Paul A., Sinha Babu S.P., Ghosh S. Haloperidol-induced catalepsy in mice and rats suppressed by orally pre-administered potentized Agaricus. Br Homeopath J 1995; 84 (01) 6-11.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 30 Tetau J., Tetau M. Pharmacologie et psychopharmacologie de Thuya. Ann Homeopath Fr 1960; 2 (08) 669-678.
    PubMedGoogle Scholar
  • 31 Tetau M., Binsard A.M., Guillemain J. Study and evaluation of coffea and Chamomilla in homeopathic dilutions on caffein-induced hyperactivity. In: LMHI Proceedings of the 35e Congres de la Ligue Médicale Homéopathique Internationale. 1982. Brighton: Liga Medicorum Homeopathica Internationalis (LMHI); 281
    Google Scholar
  • 32 Ruiz-Vega G., Perez-Ordaz L., Cortes-Galvan L., Juarez F.M. A kinetic approach to caffeine–Coffea cruda interaction. Homeopathy 2003; 92 (01) 19-29.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 33 Paul A., Sinha Babu S.P., Sukul N.C., Kurzina N.P., Batuev A.S. Effect of a potentized homoeopathic drug, Nux vomica on alcoholic rats and their hypothalamic neurons. Proc Zoolog Soc (Calcutta) 1992; 45A: 311-314.
    PubMedGoogle Scholar
  • 34 Sukul N.C., Ghosh S., Sinha Babu S.P. High dilution effects of Strychnos Nux vomica L. on hypothalamic neurons and andrenergic nerve ending of alcoholic rats. In: Taddei-Ferretti C., Marotta P. High Dilution Effects on Cells and Integrated Systems. Biophysics. Vol 3. 1998. Singapore: World Scientific; 218-223
    CrossrefGoogle Scholar
  • 35 Conforti A., Signorini A., Bellavite P. Effects of high dilutions of histamin and other natural compounds on acute inflammation in rats. In: Bornoroni C. Omeomed 92. Proceedings of the First International Congress: the Homeopathic Medicine in Europe 1993. Physical–Chemical–Biological and Clinical Research. 1993. Urbino: Editrice Compositori; 163-169
    Google Scholar
  • 36 Reber A., Poitevin B., Leroy M.-H., Nzobounsana V. Optokinetic and vestibulo-ocular reflex adjustment by GABA antagonists. Behav Brain Res 1996; 81 (01) 89-97.
    CrossrefPubMedGoogle Scholar
  • 37 Reber A., Leroy M.-H., Poitevin B. Visuo-vestibular reflexes adjustment by GABA antagonists. In: Taddei-Ferretti C., Marotta P. High Dilution Effects on Cells and Integrated Systems. Biophysics. Vol 3. 1998. Singapore: World Scientific; 259-262
    CrossrefGoogle Scholar
  • 38 Cristea A., Teodorescu-Negres S., Darie V. Chamomilla homeopathic dilution effect on central nervous system. In: Bastide M. ) Signals and Images. Selected Papers from the 7th and 8th GIRI Meeting. 1997. Dordrecht: Kluwer Academic Publishers; 171-178
    Google Scholar
  • 39 Cristea A., Teodorescu S., Paraschiv L. Experimental pharmacological researches concerning the action of Chamomilla homeopathic dilutions on central nervous systems. In: Bastide M., Wagner H., Oberbaum M., Cambar J., Halm R.P. Abstracts—Book of the 7th GIRI Meeting. 1993. Montpellier: GIRI; 23-24
    Google Scholar
  • 40 Bertani S., Andrioli G., Bellavite P., Conforti A. Dual effects of a homeopathic mineral complex on carrageenan-induced oedema in rats. Br Homeopath J 1999; 88 (03) 101-105.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 41 de Araújo Prado Neto J., Cardoso L.G.V., Bonamin L.V., Tavares Carvalho J.C. Action of Causticum in inflammatory models. Homeopathy 2004; 93 (01) 12-16.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 42 Desai V.S., Gatne M.M., Telang A.G., Ranade V.V. Anti-inflammatory activity of Arnica on carragenin induced rat paw oedema. In: IAVH Proceedings of the 3rd International Congress for Veterinary Homoeopathy of the International Association for Veterinary Homoeopathy. 1992. München: Müller & Steinicke; 89-113
    Google Scholar
  • 43 Macêdo S.B., Ferreira L.R., Perazzo F.F., Carvalho J.C.T. Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals. Homeopathy 2004; 93 (02) 84-87.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 44 Lallouette P. Approche d'une démonstration expérimentale du principe de similitude. Ann Homeopath Fr 1965; 7 (07) 492-500.
    PubMedGoogle Scholar
  • 45 Lallouette P., Boyer R. Contribution à l'étude d'une pharmacologie homéopathique. Ann Homeopath Fr 1967; 9 (07) 415-424.
    PubMedGoogle Scholar
  • 46 Lussignoli S., Bertani S., Metelmann H., Bellavite P., Conforti A. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complement Ther Med 1999; 7 (04) 225-230.
    CrossrefPubMedGoogle Scholar
  • 47 Boiron J., Abecassis J., Belon P. Action of Hahnemanian potencies upon artificially produced cancer in animals. In: Boiron J., Abecassis J., Belon P. Aspects de la Recherche en Homéopathie. 1983. Lyon: Editions Boiron; 11-18 (Chap 1)
    Google Scholar
  • 48 Rastogi D.P., Saxena A., Kumar S. Pancreatic beta-cell regeneration. A novel anti-diabetic action of Cephalendra indica mother tincture. Br Homeopath J 1988; 77 (03) 147-151.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 49 Labrecque G., Guilleminot J. Effect of Bryonia on experimental arthritis in the rat. In: Bastide M., Campbell A., Narcisse G., Halm R.P. Abstracts—Book of the 4th GIRI Meeting. 1990. Paris: GIRI; 21
    Google Scholar
  • 50 Niebauer G.W., Dorcsi M., Pfeil L. Effect of homoeopathic arnica-d-12 and actihemyl on wound-healing in the animal-experiment. Prakt Tierarzt 1980; 61 (02) 128-132.
    PubMedGoogle Scholar
  • 51 de Paula Coelho C., D'Almeida V., Pedrazzolli-Neto M. et al. Therapeutic and pathogenetic animal models for Dolichos pruriens. Homeopathy 2006; 95 (03) 136-143.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 52 Aubin M., Berjon J.J., Bildet J., Gomez H., Larrue J., Quilichini R. Etude de l'activité hépatoprotectrice de Phosphorus sur des fragments de foies de rats adultes placés en culture organotypique sur milieu artificiel après intoxication par le CCl4. Ann Homeopath Fr 1980; 22 (03) 25-33.
    PubMedGoogle Scholar
  • 53 Souza-Magro I.A., Pinto Corrado A. Reducao da nefrotoxidade induzida por aminoglicosideos. In: LMHI Proceedings of the 41st Congress of the International Homeopathic Medical League. 1986. Rio de Janeiro: Liga Medicorum Homeopathica Internationalis (LMHI); 231-233
    Google Scholar
  • 54 Boiron J., Cier A. Recherches expérimentales d'une activité isopathique. Ann Homeopath Fr 1962; 4 (10) 796-800.
    PubMedGoogle Scholar
  • 55 Boiron J. Comparaison de l'action d'Arsenicum album 7CH normal et chauffé à 120 toxication arsenicale provoquée. Homéopathie 1985; 2 (05) 49-53.
    PubMedGoogle Scholar
  • 56 Boiron J., Abecassis J., Belon P. A pharmacological study of the retention and mobilization of arsenic as caused by Hahnemanian potencies of Arsenicum Album. In: Boiron J., Abecassis J., Belon P. Aspects de la Recherche en Homéopathie. 1983. Lyon: Editions Boiron; 19-37 (Chap 2)
    Google Scholar
  • 57 Begum R., Koshy R., Sengupta A. Effect of homoeopathic drugs plumbum and opium on experimentally induced lead toxicity in rats. Indian J Exp Biol 1994; 32 (03) 192-195.
    PubMedGoogle Scholar
  • 58 Cier A., Boiron J., Quenot J. Hépatites expérimentales et essai de médications homéopathiques. Ann Homeopath Fr 1963; 5 (10) 743-755.
    PubMedGoogle Scholar
  • 59 Sur R.K., Samajdar K., Mitra S., Gole M.K., Chakravarty B.N. Hepatoprotective action of potentized Lycopodium clavatum L. Br Homeopath J 1990; 79 (03) 152-156.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 60 Möhnle U. Der Einfluß von Apis mellifica, Sulfur und ihren Lösungsmitteln bzw. Trägerstoffen auf Bienengift-induzierte Stoffwechseleffekte in der Rattenleber. Thesis, Tierärztliche Hochschule Hannover, 1987.
    PubMed
  • 61 Bildet J., Saurel J., Aubin M., Casahoursat L. Etude de l'action de divers complexes sur l'hepatite éxpérimentale du rat au tétrachlorure de carbone. Ann Homeopath Fr 1978; 20 (04) 277-287.
    PubMedGoogle Scholar
  • 62 Bildet J., Saurel J., Aubin M., Casahoursat L. Etude de l'action des diverses dilutions d'Amanita phalloides sur l'hepatite éxpérimentale du rat declenchée par le tetrachlorure de carbone. Ann Homeopath Fr 1978; 20 (04) 271-276.
    PubMedGoogle Scholar
  • 63 Bildet J. Etude de l'action de différentes dilutions homéopathiques de Phosphore blanc (Phosphorus) sur l'hépatite toxique du rat. Thesis, Université de Bordeaux II, 1975.
    PubMed
  • 64 Aubin M., Bildet J., Bergeon J.J., Dufour H. Etude histoenzymologique de l'action de diverses dilutions de Phosphorus sur l'hépatite toxique du rat au tétrachlorure de carbone. Ann Homeopath Fr 1979; 21 (04) 359-366.
    PubMedGoogle Scholar
  • 65 Centre for Experimental Medicine and Surgery IoMS. III Experimental. In: Benares Hindu University Annual Report (1985–86). 1986. Varanasi: Benares Hindu University; 22-32
    Google Scholar
  • 66 Bagros M. Phénomènes d'antagonisme et de synergie entre diverses dilutions de Folliculine. Etude expérimentale et applications thérapeutiques. Actes Soc Rhodan Homéopath 1952; 2: 52-67.
    PubMedGoogle Scholar
  • 67 Beja A. L'action biologique des dilutions infinitésimales homéopathiques de corps oestrogènes et ses conséquences thérapeutiques. Thesis, Faculté de Médecine de Paris, 1953.
    PubMed
  • 68 Boiron J., Roberfroid M., Jenaer M., Abecassis J., Lans M., de Gerlache J. Etude de l'action de dilutions hahnémanniennes d'ADN et d'ARN sur l'évolution de carcinomes provoqués chez le rat. Ann Homeopath Fr 1979; 21 (04) 401-414.
    PubMedGoogle Scholar
  • 69 de Gerlache J., Lans M. Modulation of experimental rat liver carcinogenesis by ultra low doses of the carcinogens. In: Doutremepuich C. Ultra Low Doses. 1991. London: Taylor & Francis; 17-26 (Chap 1)
    Google Scholar
  • 70 Boiron J, Roberfroid M, Belon P, Abecassis J, de Gerlache J,Lans M. Action de dilutions d'ARN/ADN sur les carcinomes provoques chez l'animal. In: Proc Congress LMHI Brighton 1982. 355–372.
    PubMed
  • 71 Sharma R.R., Agnihotri A., Gogna M.L. Experimental support for principle of dynamization, law of similiars and for new science of Ultramicroxenopathy. Hahnemann Mon 1982; 49 (01) 167-173.
    PubMedGoogle Scholar
  • 72 Wölfel B., Weingärtner O., Altenburg H.P., Raute-Kreinson U. Auswirkungen eines homöopathischen Komplexmittels (Diabetes-Gastreu R 40) auf den Blutzuckerspiegel. Ärztezeitschrift für Naturheilverfahren 1984; 25 (09) 1-5.
    PubMedGoogle Scholar
  • 73 de Caro G. Isoproterenol induced salivary gland enlargement is influenced in the rat by ultradiluted solutions of eledoisin. In: Bastide M., Campbell A., Narcisse G., Halm R.P. Abstracts—Book of the 4th GIRI Meeting. 1990. Paris: GIRI; 23
    Google Scholar
  • 74 Röhm F., Seybold G., Pirtkien R. Die verschiedenen Formen des experimentellen Ulcus ventriculi bei der Ratte und seine medikamentöse Beeinflussung. Mitteilungen der Arzneimittelforschung 1964; 14 (01) 47-50.
    PubMedGoogle Scholar
  • 75 Lallouette P., Boyer R., Martin C. Essai de démonstration expérimentale du principe de similitude. Ann Homeopath Fr 1975; 17 (04) 409-414.
    PubMedGoogle Scholar