The influence of childhood infections and vaccination on the development of atopy: A systematic review of the direct epidemiological evidence

Abstract

Background The ‘hygiene hypothesis’ has been used to justify a belief common among homeopaths, that the suppression of childhood infections and immunisation may lead to the development of chronic atopic diseases.

Objectives To analyse the influence of childhood infections and immunisation on the development of atopy.

Methods Qualitative systematic review of direct epidemiological evidence (Medline 1993–2004) concerning the influence of childhood infections and immunisation on the development of atopy and discussion based on homeopathy.

Conclusions (1) Childhood infections do not protect against atopy; on the contrary, they increase the risk of allergic diseases, in agreement to Hahnemann's observations, which included epidemic diseases among the factors capable of stimulating the development of chronic diseases. (2) Vaccination is not a risk factor for atopy, notwithstanding the allergenic effect of some vaccines.

Keywords

hygiene hypothesis - infections - vaccination - atopy - allergy - direct evidence - epidemiological review - systematic review - Hahnemann - Homeopathy

• References

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