Homeopathy 2005; 94(02): 86-91
DOI: 10.1016/j.homp.2004.10.002
ORIGINAL PAPER
Copyright ©The Faculty of Homeopathy 2005

Histamine at high dilution reduces spectral density in delta band in sleeping rats

G Ruiz-Vega
1  Laboratorio de Biofísica, Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México
,
B Poitevin
2  Association Française por la Recherche en Homeopathie
,
L Pérez-Ordaz
1  Laboratorio de Biofísica, Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México
› Author Affiliations

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Further Information

Publication History

Received02 February 2004
revised20 August 2004

accepted11 October 2004

Publication Date:
22 December 2017 (online)

Abstract

Histamine is a central neurotransmitter, it increases arousal via H1 receptors. This study examines the effect of ultra-diluted histamine on arousal through changes in the sleep pattern of Wistar rats. The spectral density in delta (0.5–2.5 Hz) band, one of the three major spectral components of the sleep-electroencephalogram, was analyzed against time. Rats were randomized to receive histamine 30c (histamine 30c, 0.05 ml every 20 min during the first 2 h orally), histamine intraperitoneal pre-treatment/histamine 30c (histamine 6 mg/kg i.p., followed by histamine 30c) or solvent control. The mean delta band spectral density was lower in the histamine 30c and histamine pretreatment/histamine 30c groups than the control group. Significant differences between histamine 30c and baseline during the first 2 h imply an immediate effect. These results also suggest a dynamic process in which the system spontaneously evolves between two locally stationary states according to a power law. From the time perspective, the system approaches, asymptotically, an equifinal state.