MCQs – from previous issue, July–December 2014

1. With reference to the KAP study from Kerala, what percentage of respondents considered epilepsy to be a contagious disease.

   • a.– Zero

   • b.– Five

   • c.– Ten

   • d.– Fifteen

2. With respect to the study from Nigeria on status epilepticus, which one of following is the least common precipitating factor for SE in developing countries.

   • a.– CNS infection

   • b.– Alcohol abuse

   • c.– AED non compliance

   • d.– Stroke

3. While comparing definitions of seizures in adults versus neonates, all of the following attributes are similar EXCEPT

   • a.– Transient nature

   • b.– Paroxysmal nature

   • c.– Signs & symptoms in motor/autonomic behaviour functions

   • d.– Abnormal neuro electrical activity

4. Which of the following transient and paroxysmal motor phenomenon in neonates is least likely to be associated with electrographic seizures

   • a.– Multifocal or fragmentary myoclonus

   • b.– Focal tonic posturing

   • c.– Bicycling movements and apnea

   • d.– Migratory clonic seizures

5. Many factors contribute to enhanced excitation of electrographic activity in neonatal brain. They include all EXCEPT

   • a.– Developmental imbalance between the maturation of excitatory and inhibitory circuits

   • b.– Low concentration of extracellular potassium in immature brain

   • c.– Hypoxia

   • d.– Hypoglycemia

6. Motor automatisms, previously called subtle seizures, are common in neonates and difficult to differentiate from non-epileptic phenomenon. Which one of the following is most likely to be a seizures manifestation.

   • a.– Slow roving eye movements

   • b.– Jittery or tremulous movements

   • c.– Stimulus sensitive myoclonus

   • d.– Sustained eye opening & fixation

7. Bening Familial Neonatal Convulsions (BFNC) is an autosomal dominant disorder involving.

   • a.– Potassium channel

   • b.– Sodium channel

   • c.– Calcium Channel

   • d.– Chloride channel

8. Early Infantile Epileptic Encephalopathy (EIEE, Ohtahara syndrome) and the Early Myoclonic Epileptic Encephalopathy (EMEE, Aicardi syndrome) share many common features EXCEPT

   • a.– Poor prognosis

   • b.– Development of hypsrhythmia around 3–6 month of age

   • c.– Clinical features of West Syndrome

   • d.– Inborn errors of metabolism

9. All True statement about Levetiracetam, EXCEPT

   • a.– Broad spectrum Antiepileptic

   • b.– Encephalopathy and behavioural disturbances may occur uncommonly

   • c.– Mostly metabolized in liver, with minimal renal elimination

   • d.– Acts on synaptic vesicle protein SV2A and prevents exocytosis

10. Two types of GM2 Gangliosidosis (Tay-Sachs and Sandhoff) have following similarities, EXCEPT

    • a.– Organomegaly

    • b.– Retinal Cherry Red Spot

    • c.– Hypomyelination

    • d.– Enlargement with abnormal signal changes in basal ganglia